1309567-74-5

Basic information

• Product Name: ethyl 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate
• Synonyms: ethyl 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate
• CAS NO: 1309567-74-5
• Molecular Weight: 409.439
• Mol File: 1309567-74-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate(1309567-74-5)
• EPA Substance Registry System: ethyl 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1,2-dihydropyridine-3-carboxylate(1309567-74-5)

Safety Data

• Hazardous Substances Data: 1309567-74-5(Hazardous Substances Data)

Upstream product

• 156635-90-4 [4-[(4-methoxyphenyl)methoxy]phenyl]boronic acid 
• 1309567-86-9 ethyl 5-bromo-4-methoxy-2-oxo-1-((2-(trimethylsilyl)ethoxy)methyl)-1,2-dihydropyridine-3-carboxylate 
• 105-56-6 ethyl 2-cyanoacetate 
• 87853-69-8 ethyl 4-methoxy-2-oxo-1,2-dihydropyridine-3-carboxylate 
• 87853-84-7 ethyl 2-cyano-3-methoxybut-2-enoate 
• 1309567-73-4 ethyl 5-bromo-4-methoxy-2-oxo-1,2-dihydropyridine-3-carboxylate 
• 1309567-89-2 ethyl 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-((2-(trimethylsilyl)ethoxy)methoxy)nicotinate 
• 1309567-88-1 ethyl 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1-((2-(trimethylsilyl) ethoxy)methyl)-1,2-dihydropyridine-3-carboxylate 

Downstream Products

• 1309567-80-3 3-((R,2E,4E)-4,6-dimethylocta-2,4-dienoyl)-4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl) pyridin-2(1H)-one 
• 1309567-81-4 3-((R,2E,4E,6E)-6,8-dimethyldeca-2,4,6-trienoyl)-4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)pyridin-2(1H)-one 
• 1309567-82-5 3-((R,2E,4E,6E,8E)-8,10-dimethyldodeca-2,4,6,8-tetraenoyl)-4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)pyridin-2(1H)-one 
• 1309567-83-6 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-3-((2E,4E,6R,8R)-4,6,8-trimethyldeca-2,4-dienoyl)pyridin-2(1H)-one 
• 1309567-84-7 4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-3-((2E,4E,6E,8R,10R)-6,8,10-trimethyldodeca-2,4,6-trienoyl)pyridin-2(1H)-one 
• 1094390-39-2 pre-tenellin B 
• 1309567-72-3 4-hydroxy-5-(4-hydroxyphenyl)-3-((2E,4E,6R,8R)-4,6,8-trimethyldeca-2,4-dienoyl)pyridin-2(1H)-one 
• 1309568-03-3 3-((S,2E,4E)-4,6-dimethylocta-2,4-dienoyl)-4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl) pyridin-2(1H)-one 
• 1309568-04-4 3-((S,2E,4E,6E)-6,8-dimethyldeca-2,4,6-trienoyl)-4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)pyridin-2(1H)-one 
• 1309568-05-5 3-((S,2E,4E,6E,8E)-8,10-dimethyldodeca-2,4,6,8-tetraenoyl)-4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)pyridin-2(1H)-one 
• 1309567-90-5 diethyl (2-(4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-oxoethyl)phosphonate 
• 1309567-75-6 dimethyl (2-(4-methoxy-5-(4-((4-methoxybenzyl)oxy)phenyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-oxoethyl)phosphonate 

Relevant articles and documents

Truncated militarinone fragments identified by total chemical synthesis induce neurite outgrowth

A group of natural products produced by entomopathogenic fungi has recently been shown to induce neurite outgrowth in the absence of nerve growth factor (NGF) in pheochromocytoma PC-12 cell culture. After completion of a total synthesis program, we continued our efforts in reducing complexity by synthetically preparing truncated analogs. Using this approach we were able to not only significantly simplify the structures but also decrease the minimum concentration needed for neuritogenic activity by a factor of 20. This activity was suppressed in the presence of an ERK1/2 inhibitor suggesting activation of the mitogen activated protein kinase (MAPK) pathway as a potential mode of action of these pyridone alkaloids. The Royal Society of Chemistry 2013.