1309803-31-3

Basic information

• Product Name: (2R,3R,4S,5R)-2-(6-amino-8-methylaminopurin-9-yl)-5-benzyloxymethyltetrahydrofuran-3,4-diol
• CAS NO: 1309803-31-3
• Molecular Weight: 386.41
• Mol File: 1309803-31-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,3R,4S,5R)-2-(6-amino-8-methylaminopurin-9-yl)-5-benzyloxymethyltetrahydrofuran-3,4-diol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R,4S,5R)-2-(6-amino-8-methylaminopurin-9-yl)-5-benzyloxymethyltetrahydrofuran-3,4-diol(1309803-31-3)
• EPA Substance Registry System: (2R,3R,4S,5R)-2-(6-amino-8-methylaminopurin-9-yl)-5-benzyloxymethyltetrahydrofuran-3,4-diol(1309803-31-3)

Safety Data

• Hazardous Substances Data: 1309803-31-3(Hazardous Substances Data)

Upstream product

• 13089-45-7 8-bromo-2',3'-O-isopropylene adenosine 
• 100-44-7 benzyl chloride 
• 87515-43-3 ((3aR,4R,6R,6aR)-6-(6-amino-8-(methylamino)-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol 

Relevant articles and documents

Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: Insights into isoform selectivity

78 kDa glucose-regulated protein (Grp78) is a heat shock protein (HSP) involved in protein folding that plays a role in cancer cell proliferation. Binding of adenosine-derived inhibitors to Grp78 was characterized by surface plasmon resonance and isothermal titration calorimetry. The most potent compounds were 13 (VER-155008) with KD = 80 nM and 14 with K D = 60 nM. X-ray crystal structures of Grp78 bound to ATP, ADPnP, and adenosine derivative 10 revealed differences in the binding site between Grp78 and homologous proteins.