1310011-61-0

Basic information

• Product Name: C₂₅H₃₁FN₄O₂
• Synonyms: C₂₅H₃₁FN₄O₂
• CAS NO: 1310011-61-0
• Molecular Weight: 438.545
• Mol File: 1310011-61-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₃₁FN₄O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₃₁FN₄O₂(1310011-61-0)
• EPA Substance Registry System: C₂₅H₃₁FN₄O₂(1310011-61-0)

Safety Data

• Hazardous Substances Data: 1310011-61-0(Hazardous Substances Data)

Upstream product

• 283584-52-1 5-fluoro-3-hydrazonoindolin-2-one 

Relevant articles and documents

Synthesis and antitumor activity of 5-[1-(3-(dimethylamino)propyl)-5- halogenated-2-oxoindolin-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3- carboxamides

We report herein the design and synthesis of novel 1-[3-(dimethylamino) propyl]indolin-2-one derivatives based on the structural features of Sunitinib, a known multitargeted receptor tyrosine kinase inhibitor, and TMP-20, a previously discovered compound with good antitumor activity in our lab. These newly synthesized derivatives were evaluated for in vitro activity against five human cancer cell lines and VEGF/bFGF-stimulated HUVECs. Results revealed that all of the target compounds 1a-p show potent antitumor activity, compounds 1e-h (IC50's: 0.45-5.08 μM) are more active than Sunitinib (IC 50's: 1.35-6.61 μM), and the most active compound 1h (IC 50: 0.47-3.11 μM) is 2.1-4.6-fold more potent than Sunitinib against all five cancer cell lines. In addition, like Sunitinib, 1a-p have higher selectivity on VEGF-stimulated HUVEC other than bFGF-stimulated HUVEC.