131003-13-9

Basic information

• Product Name: 3-Bromo-4'-fluoro-5-methyl-biphenyl-2-ol
• Synonyms: 3-Bromo-4'-fluoro-5-methyl-biphenyl-2-ol
• CAS NO: 131003-13-9
• Molecular Weight: 281.124
• Mol File: 131003-13-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Bromo-4'-fluoro-5-methyl-biphenyl-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-4'-fluoro-5-methyl-biphenyl-2-ol(131003-13-9)
• EPA Substance Registry System: 3-Bromo-4'-fluoro-5-methyl-biphenyl-2-ol(131003-13-9)

Safety Data

• Hazardous Substances Data: 131003-13-9(Hazardous Substances Data)

Upstream product

• 2432-14-6 3,5-dibromo-4-hydroxytoluene 
• 460-00-4 1-Bromo-4-fluorobenzene 

Relevant articles and documents

Arylation of Phenols. Convenient, Regiospecific Methods for Mono- or Bis-p-fluorophenylations, Suitable for Large Scale Syntheses

Phenols have been arylated by a palladium(0)-catalyzed coupling reaction.Two methods were used: a Grignard reagent of a protected phenol component 2 was coupled with a haloarene, or an umpolung (reversed reactivity) where unprotected phenolic halides 6 were coupled with aryl Grignard reagents.Bis-arylation and regiospecific ortho-, meta- and para-arylations were achieved.Aryl-aryl-couplings were insensitive to steric hindrance in the Grignard component, but were inhibited by sulfur-containing substituents in the phenolic component.A thiocyanate substituted biaryl was used to synthesize arylated phenols with various sulfur functionalities.