131029-54-4Relevant articles and documents
Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors
Tessier, Pierre,Smil, David V.,Wahhab, Amal,Leit, Silvana,Rahil, Jubrail,Li, Zuomei,Deziel, Robert,Besterman, Jeffrey M.
scheme or table, p. 5684 - 5688 (2010/04/30)
We have identified a series of diphenylmethylene hydroxamic acids as novel and selective HDAC class IIa inhibitors. The original hit, N-hydroxy-2,2-diphenylacetamide (6), has sub-micromolar class IIa HDAC inhibitory activity, while the rigidified oxygen a
Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents
Knutsen, Lars J. S.,Andersen, Knud Erik,Lau, Jesper,Lundt, Behrend F.,Henry, Rodger F.,Morton, Howard E.,N?rum, Lars,Petersen, Hans,Stephensen, Henrik,Suzdak, Peter D.,Swedberg, Michael D. B.,Thomsen, Christian,S?rensen, Per O.
, p. 3447 - 3462 (2007/10/03)
(3R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid 1 (tiagabine, Gabitril) is a potent and selective γ-aminobutyric acid (GABA) uptake inhibitor with proven anticonvulsant efficacy in humans. This drug, which has a unique mechanism
Isoindolone derivatives
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, (2008/06/13)
New isoindolone derivatives of general formula (I) are STR1 disclosed in which the radicals R represent hydrogen atoms or, together, form a bond, the symbol R' represents a hydrogen atom or a readily removable radical and the symbols R" are identical and