131043-44-2Relevant articles and documents
Efficient solid-phase synthesis of highly functionalized 1,4-benzodiazepin-5-one derivatives and related compounds by intramolecular aza-wittig reactions
Gil, Carmen,Braese, Stefan
, p. 2680 - 2688 (2005)
Due to their widespread biological activities and favorable pharmacokinetic properties, benzodiazepines were among the first classes of small molecules to be synthesized on solid supports. Since then, there have been numerous reports on the synthesis of similar skeletons. We have employed the T1 triazene linker to yield 1,4-benzodiazepin-5-one. Starting from various substituted triazene resins, cleavage in the presence of an azide donor, such as trimethylsilylazide, gave rise to aryl azides. Intramolecular aza-Wittig reactions produced the appropriately functionalized N-heterocycles. By using this route, the natural product deoxyvasicinone and related compounds were prepared.
One pot conversion of azido arenes to N-arylacetamides and N-arylformamides: Synthesis of 1,4-benzodiazepine-2,5-diones and fused [2,1-b]quinazolinones
Kamal, Ahmed,Ramana, A. Venkata,Reddy, K. Srinivasa,Ramana, K. Venkata,Hari Babu,Prasad, B. Rajendra
, p. 8187 - 8190 (2007/10/03)
Sodium iodide in acidic media has been employed for the synthesis of N-arylformamides and N-arylacetamides. The NaI/acetic acid reagent system has also been extended for the synthesis of 1,4-benzodiazepine-2,5-diones, pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones, and fused [2,1-b]quinazolinones.
Novel Ring Enlargement of Lactams via Quinazolinone Annelation. A Facile Route to Benzoannelated Large-Membered Cyclic 1,5-Diamines
Takeuchi, Hisato,Matsushita, Yuji,Eguchi, Shoji
, p. 1535 - 1537 (2007/10/02)
A novel route to benzoannelated large-membered cyclic 1,5-diamines from lactams is described.Thus, n-membered lactames 1 were N-acylated by o-azidobenzoyl chloride 5 to afford the corresponding imides 4.These were treated with tributylphosphine and underw
