1310716-21-2

Basic information

• Product Name: C₂₂H₂₄F₃NO₃Si
• CAS NO: 1310716-21-2
• Molecular Weight: 435.518
• Mol File: 1310716-21-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₄F₃NO₃Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₄F₃NO₃Si(1310716-21-2)
• EPA Substance Registry System: C₂₂H₂₄F₃NO₃Si(1310716-21-2)

Safety Data

• Hazardous Substances Data: 1310716-21-2(Hazardous Substances Data)

Upstream product

• 659-28-9 p-trifluoromethoxybenzaldehyde 
• 106792-38-5 5-(tert-butyl-dimethyl-silanyloxy)-1H-indole 

Downstream Products

• 1282035-28-2 C₁₆H₁₀F₃NO₃ 

Relevant articles and documents

Structure and activity relationship of 2-(substituted benzoyl)- hydroxyindoles as novel CaMKII inhibitors

A series of novel 2-substituted-5-hydroxyindoles were synthesized and evaluated for their inhibitory activity against CaMKII. Structure and activity relationship results indicated that potent inhibitory activity could be achieved by modification at the para-position of the phenyl ring of the high throughput screening hit compound 2. Among the prepared compounds, we identified 14 as a novel CaMKII inhibitor with an activity stronger than that of KN-93, a known CaMKII inhibitor.