1310802-74-4Relevant articles and documents
Asymmetric synthesis of (-)-chicanine using a highly regioselective intramolecular Mitsunobu reaction and revision of its absolute configuration
Harada, Kenichi,Horiuchi, Hiroki,Tanabe, Kazuma,Carter, Rich G.,Esumi, Tomoyuki,Kubo, Miwa,Hioki, Hideaki,Fukuyama, Yoshiyasu
, p. 3005 - 3008 (2011/06/23)
First asymmetric synthesis of (-)-chicanine has been accomplished in 14 steps by employing the Evans asymmetric syn-selective aldol reaction, diastereoselective hydroboration and an regioselective, intramolecular Mitsunobu etherification. The absolute configuration of (+)- and (-)-chicanine has been revised to 2R,3S,4R,5R and 2S,3R,4S,5S, respectively, through CD analysis.