1311141-25-9

Basic information

• Product Name: 5'-O-(4,4'-dimethoxytrityl)-N₄-acetyl-5-formyl-2'-deoxycytidine 3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
• Synonyms: 5'-O-(4,4'-dimethoxytrityl)-N₄-acetyl-5-formyl-2'-deoxycytidine 3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
• CAS NO: 1311141-25-9
• Molecular Weight: 799.861
• Mol File: 1311141-25-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5'-O-(4,4'-dimethoxytrityl)-N₄-acetyl-5-formyl-2'-deoxycytidine 3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(4,4'-dimethoxytrityl)-N₄-acetyl-5-formyl-2'-deoxycytidine 3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite(1311141-25-9)
• EPA Substance Registry System: 5'-O-(4,4'-dimethoxytrityl)-N₄-acetyl-5-formyl-2'-deoxycytidine 3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite(1311141-25-9)

Safety Data

• Hazardous Substances Data: 1311141-25-9(Hazardous Substances Data)

Upstream product

• 1257247-38-3 5-formyl-3′,5′-bis-(tert-butyl-dimethylsilyl)-2′-deoxy-cytidine 
• 142667-68-3 3',5'-bis-O-(tert-butyldimethylsilyl)-5-(formyl)-2'-deoxyuridine 
• 354581-59-2 3',5'-bis(O-tert-butyldimethylsilyl)-5-hydroxymethyl-2'-deoxyuridine 
• 40733-26-4 3',5'-O-di(tert-butyldimethylsilyl)thymidine 
• 50-89-5 thymidine 
• 611-53-0 5-Iodo-2'-deoxycytidine 
• 1311141-18-0 3',5'-O-di-t-butylsilyl-5-formyl-2'-deoxycytidine 
• 1311141-17-9 3',5'-O-di-tert-butylsilyl-5-iodo-2'-deoxycytidine 
• 1311141-21-5 5'-O-(4,4'-dimethoxytrityl)-N₄-acetyl-5-formyl-2'-deoxycytidine 
• 124482-92-4 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine 
• 1311141-20-4 N₄-acetyl-5-formyl-2'-deoxycytidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 1311141-19-1 3',5'-O-di-t-butylsilyl-N₄-acetyl-5-formyl-2'-deoxycytidine 

Relevant articles and documents

Catalytic Space Engineering as a Strategy to Activate C-H Oxidation on 5-Methylcytosine in Mammalian Genome

Conditional remodeling of enzyme catalysis is a formidable challenge in protein engineering. Herein, we have undertaken a unique active site engineering tactic to command catalytic outcomes. With ten-eleven translocation (TET) enzyme as a paradigm, we show that variants with an expanded active site significantly enhance multistep C-H oxidation in 5-methylcytosine (5mC), whereas a crowded cavity leads to a single-step catalytic apparatus. We further identify an evolutionarily conserved residue in the TET family with a remarkable catalysis-directing ability. The activating variant demonstrated its prowess to oxidize 5mC in chromosomal DNA for potentiating expression of genes including tumor suppressors.