13114-91-5

Basic information

• Product Name: Urea, N-(2-bromophenyl)-N'-phenyl-
• CAS NO: 13114-91-5
• Molecular Formula: C13H11BrN2O
• Molecular Weight: 291.147
• Mol File: 13114-91-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Urea, N-(2-bromophenyl)-N'-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Urea, N-(2-bromophenyl)-N'-phenyl-(13114-91-5)
• EPA Substance Registry System: Urea, N-(2-bromophenyl)-N'-phenyl-(13114-91-5)

Safety Data

• Hazardous Substances Data: 13114-91-5(Hazardous Substances Data)

Upstream product

• 304690-59-3 (1H-benzo[d][1,2,3]triazol-1-yl)(2-bromophenyl)methanone 
• 62-53-3 aniline 
• 4231-62-3 1-benzoyl-1H-benzotriazole 
• 615-36-1 2-bromoaniline 
• 95-14-7 1,2,3-Benzotriazole 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 1592-00-3 2-bromophenyl isocyanate 
• 103-71-9 phenyl isocyanate 
• 50625-50-8 2-bromo-benzoyl azide 

Downstream Products

• 14813-85-5 1-phenyl-1,3-dihydrobenzoimidazol-2-one 
• 1026-16-0 2-(phenylamino)-4H-benzo[d][1,3]oxazin-4-one 
• 4248-15-1 2-anilinoquinazolin-4(3H)-one 
• 862891-90-5 1-benzyl-1-(2-bromophenyl)-3-phenylurea 

Relevant articles and documents

Chiral Non-Planar Oligophenylenes Bridged by Urea Linkage: Synthesis through Intramolecular Direct Arylation, Chiroptical Behavior, and Theoretical Investigation

The intramolecular direct arylation of N,N′-dihexyl-N-(2-bromophenyl)-N′-phenylurea using palladium catalyst gave BPU in 75 % yield. Longer terphenyl compound (TPbU) was likewise prepared. Other four conjugated oligomers (BPtU, BPU-1Np, BPU-2Np, and BPU-A

Synthetic method and application of urea compound

The invention relates to a synthetic method of a urea compound, comprising the following steps: adding substituted oxazolone and sodium acetate into a methanol solution, and adding substituted amine under the stirring condition, reacting and carrying out column chromatography to obtain the urea compound. The defect that dangerous compounds need to be used during existing synthetic process is overcome, and a one-pot method is adopted to replace an existing reaction with low yield. The method of the invention has mild reaction condition, the operation is simple, raw materials are easily available, and the substrate can be converted into various other useful molecules. The compound has strong practicality, and can be applied to synthesis of the pesticide daimuron, dieresis long and the anti-cancer drug Sorafenib. The invention relates to a green and environmentally-friendly unsymmetrical urea compound synthesis method with simple process and low cost.

Unsymmetrically disubstituted urea derivatives: A potent class of antiglycating agents

A series of unsymmetrically disubstituted urea derivatives 1-28 has been synthesized and screened for their antiglycation activity in vitro. Compounds 26 (IC50 = 4.26 ± 0.25 μM), 1 (IC50 = 5.8 ± 0.08 μM), 22 (IC50 = 4.26 ± 0.25 μM), 6 (IC50 = 6.4 ± 0.02 μM), 5 (IC50 = 6.6 ± 0.26 μM), 2 (IC50 = 7.02 ± 0.31 μM), 3 (IC50 = 7.14 ± 0.84 μM), 27 (IC50 = 7.27 ± 0.36 μM), 4 (IC50 = 8.16 ± 1.04 μM), 21 (IC50 = 8.4 ± 0.15 μM), 23 (IC50 = 9.0 ± 0.35 μM) and 13 (IC50 = 15.22 ± 6.7 μM) showed an excellent antiglycation activity far better than the standard (rutin, IC50 = 41.9 ± 2.3 μM). This study thus provides a series of potential molecules for further studies of antiglycation agents.