131179-95-8 Usage
Description
Efaproxiral, also known as an allosteric hemoglobin (Hb) modifier, is a compound that reduces the affinity of Hb for oxygen, thereby increasing the diffusion of oxygen from blood to tissue. It is characterized by its off-white to tan solid appearance and plays a significant role in enhancing oxygen delivery to tissues, particularly in hypoxic conditions.
Uses
Used in Anticancer Applications:
Efaproxiral is used as an antineoplastic adjunct (radiosensitizer) for enhancing radiation-induced cytotoxicity in cancer cells grown under hypoxic conditions. It increases radiosensitization and inhibits tumor growth in hypoxic tumor models when administered at specific doses.
Used in Enhancing Oxygen Delivery:
Efaproxiral is used as an allosteric modifier of hemoglobin (HB) to increase the partial pressure of oxygen at which Hb is 50% saturated (p50) and decrease the percent oxyhemoglobin (Hb-O2) saturation at a given partial oxygen pressure (pO2). This modification improves oxygen delivery to tissues, which can be beneficial in various medical conditions where oxygen supply is compromised.
Used in Cardiovascular Applications:
Efaproxiral is used to increase the running capacity of normal mice and mice with left coronary artery (LCA) ligation-induced myocardial infarction (MI) when administered at a specific dose. This application highlights its potential in improving oxygen supply to the heart and enhancing cardiac function in certain conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 131179-95-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,1,7 and 9 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 131179-95:
(8*1)+(7*3)+(6*1)+(5*1)+(4*7)+(3*9)+(2*9)+(1*5)=118
118 % 10 = 8
So 131179-95-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H23NO4/c1-13-9-14(2)11-16(10-13)21-18(22)12-15-5-7-17(8-6-15)25-20(3,4)19(23)24/h5-11H,12H2,1-4H3,(H,21,22)(H,23,24)
131179-95-8Relevant articles and documents
Trimethylaluminium mediated amide bond formation in a continuous flow microreactor as key to the synthesis of rimonabant and efaproxiral
Gustafsson, Tomas,Ponten, Fritiof,Seeberger, Peter H.
, p. 1100 - 1102 (2008/09/21)
A safe, functional-group-tolerant and high-throughput version of the trimethylaluminium mediated amide bond formation reaction has been developed in a microreactor system; rimonabant and efaproxiral were prepared to illustrate the utility of the method. The Royal Society of Chemistry.
Selective phenol alkylation: An improved preparation of efaproxiral
Anderson, Joanne,Davis, Roman,Fitzgerald, Russ,Haberman, Jannine
, p. 2129 - 2133 (2007/10/03)
An improved, two-step synthesis of efaproxiral, used in breast cancer therapy, is described, utilizing inexpensive commodity chemicals for starting materials. Selective amide formation and O-alkylation in the presence of multireactive functional groups is demonstrated, thus avoiding protection/deprotection steps. Copyright Taylor & Francis Group, LLC.
