131195-91-0

Basic information

• Product Name: Propanamide, N-(2,4-dichlorophenyl)-2,2-dimethyl-
• CAS NO: 131195-91-0
• Molecular Formula: C11H13Cl2NO
• Molecular Weight: 246.136
• Mol File: 131195-91-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Propanamide, N-(2,4-dichlorophenyl)-2,2-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, N-(2,4-dichlorophenyl)-2,2-dimethyl-(131195-91-0)
• EPA Substance Registry System: Propanamide, N-(2,4-dichlorophenyl)-2,2-dimethyl-(131195-91-0)

Safety Data

• Hazardous Substances Data: 131195-91-0(Hazardous Substances Data)

Upstream product

• 3282-30-2 pivaloyl chloride 
• 95-51-2 o-chloroaniline 
• 62662-74-2 N-(2-chlorophenyl)-2,2,2-trimethylacetamide 
• 65854-91-3 N-(4-chlorophenyl)-2,2-dimethylpropionamide 
• 554-00-7 2,4-Dichloroaniline 

Downstream Products

• 922162-63-8 N-(2,4-dichloro-6-[hydroxy(2-methoxyphenyl)methyl]-phenyl)-2,2-dimethylpropanamide 
• 1334531-22-4 ethyl (3S)-1-(4-[(2,4-dichloro-6-[(S)-hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate 
• 922161-21-5 4-[(2,4-dichloro-6-[hydroxy(2-methoxyphenyl)methyl]-phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoic acid 
• 922161-20-4 methyl 4-[(2,4-dichloro-6-[hydroxy(2-methoxyphenyl)methyl]phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoate 
• 152911-71-2 (3,5-dichloro-2-[(2,2-dimethylpropyl)amino]phenyl)-(2-methoxyphenyl)methanol 
• 131195-92-1 N-pivaloyl-4-chloro-2-(phenylthio)aniline 

Relevant articles and documents

Preparation method of ortho-amino trifluoroacetophenone and derivatives thereof

The invention relates to the field of organic synthesis, in particular to a preparation method of ortho-amino trifluoroacetophenone and derivatives thereof. The preparation of ortho-amino trifluoroacetophenone comprises three steps of amino protection, trifluoroacetylation and deprotection, the overall reaction condition is mild, the yield is high, and the method is suitable for large-scale production. In addition, on the basis of the preparation, substitution is carried out after amino diazotization, the ortho-amino trifluoroacetophenone derivative is further prepared, and the industrial application prospect is good.

Efficient Electrocatalysis for the Preparation of (Hetero)aryl Chlorides and Vinyl Chloride with 1,2-Dichloroethane

Although the application of 1,2-dichloroethane (DCE) as a chlorinating reagent in organic synthesis with the concomitant release of vinyl chloride as a useful byproduct is a fantastic idea, it still presents a tremendous challenge and has not yet been achieved because of the harsh dehydrochlorination conditions and the sluggish C?H chlorination process. Here we report a bifunctional electrocatalysis strategy for the catalytic dehydrochlorination of DCE at the cathode simultaneously with anodic oxidative aromatic chlorination using the released HCl as the chloride source for the efficient synthesis of value-added (hetero)aryl chlorides. The mildness and practicality of the protocol was further demonstrated by the efficient late-stage chlorination of bioactive molecules.

Discovery of atrop fixed alkoxy-aminobenzhydrol derivatives: Novel, highly potent and orally efficacious squalene synthase inhibitors

We have recently reported the discovery of the new benzhydrol template, which has a highly potent inhibitory activity for squalene synthase, as typified by compound 1 (SSI IC50 = 0.85 nM). However, it was composed of a pair of easy rotatable at