13122-89-9Relevant articles and documents
Peptide synthesis in room temperature ionic liquids
Vallette, Hélène,Ferron, Laurent,Coquerel, Gérard,Gaumont, Annie-Claude,Plaquevent, Jean-Christophe
, p. 1617 - 1619 (2004)
We demonstrate that chemical peptide coupling using modern coupling agents is efficient in rt ionic liquids. This new approach presents some advantages, especially in the case of hindered amino acids, which are not easy to couple under standard conditions
Di-tert-butyl dicarbonate: A novel reagent for the efficient synthesis of dipeptides under mild conditions
Mohapatra, Debendra K.,Datta, Apurba
, p. 6879 - 6880 (1999)
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BOMI - A novel peptide coupling reagent
Li, Peng,Xu, Jie Cheng
, p. 3605 - 3608 (1999)
A novel coupling reagent, benzotriazol-1-yloxy-N,N- dimethylmethaniminium hexachloroantimonate (BOMI), was synthesized and successfully applied to the synthesis of oligopeptides, the racemization and the influence of several reaction parameters such as so
Zn-Catalyzed Nicotinate-Directed Transamidations in Peptide Synthesis
Hollanders, Charlie,Renders, Evelien,Gadais, Charlène,Masullo, Dario,Van Raemdonck, Laurent,Wybon, Clarence C. D.,Martin, Charlotte,Herrebout, Wouter A.,Maes, Bert U. W.,Ballet, Steven
, p. 4280 - 4289 (2020)
A chemoselective and catalytic transamidation for peptide synthesis is described. Transamidation under Zn catalysis is chemoselectively achieved by amino acid amide/peptidic amide derivatization with a tert-butyl nicotinate (tBu-nic) directing group. The directing group could be easily introduced on protected amino acid amides via Pd-catalyzed amidation with tert-butyl 2-chloronicotinate (tBu-nicCl). Under standard peptide coupling/deprotection conditions, the tBu-nic-equipped amino acid amides proved to be fully inert, allowing them to be easily built-in in complex molecules. The disclosed method was evaluated in the synthesis of diverse dipeptides, in dipeptide segment coupling, in side-chain modification of a solid-supported tetra-/pentapeptide, and in the macrocyclization of a heptapeptide.
Effect of Stereochemistry on Chirality and Gelation Properties of Supramolecular Self-Assemblies
Qin, Minggao,Zhang, Yaqian,Xing, Chao,Yang, Li,Zhao, Changli,Dou, Xiaoqiu,Feng, Chuanliang
, p. 3119 - 3129 (2021/01/20)
Although chiral nanostructures have been fabricated at various structural levels, the transfer and amplification of chirality from molecules to supramolecular self-assemblies are still puzzling, especially for heterochiral molecules. Herein, four series o
Controlling Amphiphilic Polymer Folding beyond the Primary Structure with Protein-Mimetic Di(Phenylalanine)
Dykeman-Bermingham, Peter A.,Knight, Abigail S.,Warren, Jacqueline L.
supporting information, p. 13228 - 13234 (2021/09/03)
While methods for polymer synthesis have proliferated, their functionality pales in comparison to natural biopolymers-strategies are limited for building the intricate network of noncovalent interactions necessary to elicit complex, protein-like functions
