1312207-99-0

Basic information

• Product Name: 1-{[2-(ethylamino)ethyl]amino}-3-[4-(trifluoromethyl)phenyl]benzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile
• CAS NO: 1312207-99-0
• Molecular Weight: 423.441
• Mol File: 1312207-99-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-{[2-(ethylamino)ethyl]amino}-3-[4-(trifluoromethyl)phenyl]benzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-{[2-(ethylamino)ethyl]amino}-3-[4-(trifluoromethyl)phenyl]benzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile(1312207-99-0)
• EPA Substance Registry System: 1-{[2-(ethylamino)ethyl]amino}-3-[4-(trifluoromethyl)phenyl]benzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile(1312207-99-0)

Safety Data

• Hazardous Substances Data: 1312207-99-0(Hazardous Substances Data)

Upstream product

• 106263-53-0 ethyl 3-oxo-3-(4-(trifluoromethyl)phenyl)propanoate 
• 4414-88-4 1H-benzimidazol-2-acetonitrile 
• 110-72-5 N-ethylethane-1,2-diamine 
• 1312208-19-7 1-chloro-3-[4-(trifluoromethyl)phenyl]benzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile 

Relevant articles and documents

Antimalarial Pyrido[1,2-a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model

Further structure-activity relationship (SAR) studies on the recently identified pyrido[1,2-a]benzimidazole (PBI) antimalarials have led to the identification of potent, metabolically stable compounds with improved in vivo oral efficacy in the P. berghei mouse model and additional activity against parasite liver and gametocyte stages, making them potential candidates for preclinical development. Inhibition of hemozoin formation possibly contributes to the mechanism of action.