1312356-08-3Relevant articles and documents
1-Hydroxypyrido[2,3-d]pyrimidin-2(1H)-ones as novel selective HIV integrase inhibitors obtained via privileged substructure-based compound libraries
Gao, Ping,Zhang, Lingzi,Sun, Lin,Huang, Tianguang,Tan, Jing,Zhang, Jian,Zhou, Zhongxia,Zhao, Tong,Menéndez-Arias, Luis,Pannecouque, Christophe,Clercq, Erik De,Zhan, Peng,Liu, Xinyong
, p. 5779 - 5789 (2017/09/28)
A small library containing 3-hydroxyquinazoline-2,4(1H,3H)-dione and 1-hydroxypyrido[2,3-d]pyrimidin-2(1H)-one scaffolds was obtained via the copper(I)-catalyzed azidealkyne cycloaddition (CuAAC) reaction and evaluated for their anti-HIV activity in MT-4
Pyridopyrimidinone inhibitors of HIV-1 RNase H
Velthuisen, Emile J.,Johns, Brian A.,Gerondelis, Peter,Chen, Yan,Li, Ming,Mou, Ke,Zhang, Wenwen,Seal, John W.,Hightower, Kendra E.,Miranda, Sonia R.,Brown, Kevin,Leesnitzer, Lisa
, p. 609 - 616 (2014/07/21)
Using a structure based pharmacophore design, a weak inhibitor of RNase H, identified from a small library of two metal binding HIV-1 integrase inhibitors, was optimized for potency and physicochemical properties. This manuscript describes the SAR and in vivo DMPK for the pyridopyrimidinone class of inhibitors.