13124-18-0

Basic information

• Product Name: (3,4-dichlorophenyl)hydrazine
• Synonyms: DICHLOROPHENYLHYDRAZINE;1-(3,4-Dichlorophenyl)hydrazine;Einecs 236-057-5;1,2-Dichloro-4-hydrazinobenzene
• CAS NO: 13124-18-0
• Molecular Formula: C₆H₆Cl₂N₂
• Molecular Weight: 177.0312
• EINECS: 236-057-5
• Mol File: 13124-18-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 73-75 °C
• Boiling Point: 288.3°Cat760mmHg
• Flash Point: 128.2°C
• Appearance: /
• Density: 1.475g/cm³
• Vapor Pressure: 0.00236mmHg at 25°C
• Refractive Index: 1.665
• Storage Temp.: 2-8°C
• PKA: 4.72±0.24(Predicted)
• CAS DataBase Reference: (3,4-dichlorophenyl)hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (3,4-dichlorophenyl)hydrazine(13124-18-0)
• EPA Substance Registry System: (3,4-dichlorophenyl)hydrazine(13124-18-0)

Safety Data

• Hazardous Substances Data: 13124-18-0(Hazardous Substances Data)

Usage

General Description

(3,4-dichlorophenyl)hydrazine is a chemical compound with the molecular formula C6H6Cl2N2. It is a hydrazine derivative that is commonly used in organic synthesis and pharmaceutical research. The compound is a colorless to pale yellow liquid with a pungent odor, and it is classified as a hazardous substance due to its potential health effects. It has been studied for its potential use in the treatment of cancer and tuberculosis, and it is also used as a precursor in the synthesis of various pharmaceuticals and agrochemicals. However, it is important to handle this chemical with caution due to its toxic and potentially carcinogenic properties.

InChI:InChI=1/C6H6Cl2N2/c7-5-2-1-4(10-9)3-6(5)8/h1-3,10H,9H2

Upstream product

• 30930-66-6 3,4-dichlorobenzenediazonium cation 
• 19763-90-7 3,4-dichlorophenylhydrazine hydrochloride 
• 95-76-1 m,p-dichloroaniline 
• 50379-99-2 3,4-dichlorobenzenediazonium chloride 

Downstream Products

• 1033725-92-6 1-(3,4-dichlorophenyl)-3-methyl-4,5-dihydropyrazole 
• 1225468-42-7 (Z)-1-(3,4-dichlorophenyl)-4-(4-ethoxy-3-methoxybenzylidene)-3-methyl-1H-pyrazol-5(4H)-one 
• 1259490-47-5 2-benzyl-6,7-dichloro-2,3,4,9-tetrahydro-1H-carbazol-1-one 
• 1259490-48-6 2-benzyl-5,6-dichloro-2,3,4,9-tetrahydro-1H-carbazol-1-one 
• 1259490-27-1 2-benzyl-6,7-dichloro-9H-carbazol-1-ol 
• 1259490-28-2 2-benzyl-5,6-dichloro-9H-carbazol-1-ol 
• 1322474-67-8 2-benzylidene-6,7-dichloro-2,3,4,9-tetrahydro-1H-carbazol-1-one 
• 1322474-61-2 2-benzylidene-5,6-dichloro-2,3,4,9-tetrahydro-1H-carbazol-1-one 
• 1322473-35-7 C₁₉H₁₅Cl₂NO₃S 
• 1322473-43-7 C₁₉H₁₅Cl₂NO₃S 
• 1219443-91-0 1-methylindole-3-carboxaldehyde (3,4-dichlorophenyl)hydrazone 
• 951779-12-7 C₁₅H₁₁Cl₃F₃N₃O₂S 
• 1158813-61-6 N'-(3,4-dichlorophenylhydrazinocarbonyl)acetic acid methyl ester 
• 13124-09-9 3,4-dichlorophenylthiosemicarbazide 

Relevant articles and documents

Regioselective radical arylation of anilines with arylhydrazines

Substituted 2-aminobiphenyls have been prepared from arylhydrazines and anilines via radical arylation reactions under simple oxidative conditions. The strong directing effect of the free and unprotonated amino functionality leads to high regioselectivities, and anilines have been shown to be significantly better aryl radical acceptors than nitrobenzenes or phenyl ethers. The methodology is also applicable to phenols, which react best as phenolates under strongly basic conditions. Finally, radical arylation reactions of anilines and anilinium salts under various conditions have for the first time demonstrated that regioselectivity can also be controlled through the rearomatization step and that the addition of an aryl radical to a substituted benzene might even be reversible.

AN EFFICIENT METHOD FOR THE CONVERSION OF ARYLHYDRAZINES INTO 2-ARYL-4,4-DIALKYLSEMICARBAZIDES

Arylhydrazines are converted into 2-aryl-4,4-dialkylsemicarbazides by subsequent reaction with chloroformate, phosgene, dialkylamine, and alkaline hydrolysis.

Pyrazol-4-acetic acid compounds

Pyrazol-4-acetic acid compounds, such as substituted pyrazol-4-acetic acid, its esters, amides, nitriles and their pharamaceutically acceptable salts and method for the preparation of these compounds are disclosed. The novel compounds are useful analgesics, anti-inflammatory, and antipyretics.