13124-61-3Relevant articles and documents
Divergent Synthesis of Highly Substituted Pyridines and Benzenes from Dienals, Alkynes, and Sulfonyl Azides
Luo, Han,Li, You,Du, Luan,Xin, Xiaolan,Wang, Tao,Han, Jingpeng,Tian, Yi,Li, Baosheng
supporting information, p. 7883 - 7887 (2021/10/20)
Divergent synthesis is extremely important for the highly efficient preparation of structurally diverse target molecules. Herein, we describe a multicomponent cascade reaction, which allows access to highly substituted pyridines and benzenes by combining four individual steps in a one-pot manner from the same set of readily available starting materials. The azepine intermediates were first used as the precursors for 6π-electrocyclization to construct highly substituted pyridines and benzenes in a tunable manner.
Nickel-catalyzed cross-coupling of aryl fluorides and organozinc reagents
Zhu, Feng,Wang, Zhong-Xia
, p. 4285 - 4292 (2014/06/09)
Ni(PCy3)2Cl2 was demonstrated to effectively catalyze cross-coupling of aryl fluorides and organozinc reagents. Both electron-poor and -rich aryl fluorides can react effectively with nucleophiles including aryl-, methyl-, and benzylzinc chlorides. A wide range of substituents and functional groups are tolerated. In the presence of a directing group, PhC(O), the reaction is selective for cleavage of the C-F bond ortho to the carbonyl substituent in a difluoroarene.
Nickel-catalyzed cross-coupling of non-activated or functionalized aryl halides with aryl grignard reagents
Xie, Lan-Gui,Wang, Zhong-Xia
supporting information; experimental part, p. 10332 - 10336 (2010/10/21)
Figure Presented New nickel complexes can efficiently catalyze cross-coupling of unactivated and deactivated aryl chlorides and fluorides with aryl Grignard reagents. The reaction can tolerate functional groups in aryl chlorides with or without the aid of additives, depending on the substrates (see scheme).