13127-18-9Relevant articles and documents
Translactonization of erythromycin a during oximation: Mixture analysis and reaction monitoring by NMR
Grover, Rajesh K.,Joshi,Batra,Roy, Raja,Bhaduri
, p. 355 - 360 (2001)
Oximation of erythromycin A with hydroxylamine hydrochloride and sodium acetate in methanol led to the formation of pseudoerythromycin A enol ether with erythromycin A oxime as analysed by detailed two-dimensional NMR spectroscopy in the mixture along with traces of 8,9-anhydroerythromycin A 6,9-hemiketal and erythromycin A 6,9:9,12-spiroketal. The formation of the degraded products was established by performing in situ 13C NMR spectroscopy. The analysis suggests that pseudoerythromycin A enol ether is formed by the translactonization of erythromycin A enol ether which forms as a result of acid degradation. Copyright
Synthesis of two and antibacterial activity of one novel oxime ether derivatives of erythromycin A
Dondas,Yaktubay
, p. 1011 - 1015 (2003)
The synthesis of novel erythromycin A 9-O-(2-ethenesulfony-ethyl)-oxime and erythromycin A 9-O-(3-oxo-butyl)-oxime from erythromycin A (EA) by the Michael reaction is described and to describe the effects of transformation of ketone in position 9 of EA to an oxime ether. This transformation occurred in a single step without protecting of any functional moiety of erythromycin oxime and zero waste manner in good yield. The antibacterial screen of EA 9-O-(2-ethenesulfony-ethyl)-oxime is also reported.
Synthetic method of isotope-labeled erythromycylamine
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Paragraph 0020; 0025-0027; 0033-0035; 0041-0043, (2020/07/28)
The invention discloses a synthetic method of isotope-labeled erythromycylamine, belongs to the field of drug metabolism, and provides a synthetic method which is reasonable in process design, strongin operability and high in yield, can efficiently convert isotope-labeled raw materials into labeled target products, and can realize industrial production of isotope-labeled erythromycylamine. The method takes 13CD3 labeled methyl iodide as a starting raw material, the isotope-labeled erythromycylamine is synthesized by six steps of reactions, optimal preparation steps and reaction conditions arescreened out through a large number of experiments, the whole process is reasonable in design and high in operability, the labeled raw materials can be efficiently converted into labeled target products, the chemical purity of the labeled erythromycylamine prepared through the method can reach 98.5% or above, and the labeled isotope abundance is larger than 98.5%.
Preparation method of erythromycin A oxime
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Page/Page column 5, (2017/08/31)
The invention belongs to the technical field of medical chemistry and particularly relates to a preparation method of erythromycin A oxime. The method has the advantages of being simple in operation, high in yield and good in product purity and suitable for large-scale industrial production.