131339-23-6 Usage
Description
17,18-epoxy-5,8,11,14-eicosatetraenoic acid, also known as EpETE, is a unique eicosapentaenoic acid (EPA) derivative obtained through the formal epoxidation of the 17,18-double bond of all-cis-5,8,11,14,17-icosapentaenoic acid. 17,18-epoxy-5,8,11,14-eicosatetraenoic acid exhibits distinct chemical and biological properties, making it a valuable substance for various applications.
Uses
Used in Pharmaceutical Industry:
17,18-epoxy-5,8,11,14-eicosatetraenoic acid is used as a pharmaceutical agent for its potential therapeutic effects. The unique epoxy structure endows it with properties that can modulate biological pathways and exhibit beneficial pharmacological actions. Its specific application in the pharmaceutical industry may include the treatment of various diseases and conditions, given its ability to interact with cellular targets and signaling pathways.
Used in Research Applications:
In the field of scientific research, 17,18-epoxy-5,8,11,14-eicosatetraenoic acid serves as a valuable tool for studying the biological roles and mechanisms of action of EPA and its derivatives. It can be utilized in experiments to investigate the effects of epoxy fatty acids on cellular processes, signaling pathways, and disease progression. This knowledge can contribute to the development of novel therapeutic strategies and a deeper understanding of lipid-mediated biological processes.
Used in Nutraceutical Industry:
17,18-epoxy-5,8,11,14-eicosatetraenoic acid can be employed as a nutraceutical ingredient, capitalizing on its potential health benefits. Given its origin from EPA, a well-known omega-3 fatty acid with established health-promoting properties, the epoxy derivative may offer enhanced or complementary benefits. It could be incorporated into supplements or functional foods to support overall health and well-being.
Used in Cosmetic Industry:
The unique properties of 17,18-epoxy-5,8,11,14-eicosatetraenoic acid may also find applications in the cosmetic industry. Its potential to modulate biological processes and interact with cellular targets could translate into beneficial effects on skin health, such as anti-aging, moisturizing, or protective properties. As a result, it could be incorporated into skincare products to enhance their efficacy and provide consumers with added benefits.
Check Digit Verification of cas no
The CAS Registry Mumber 131339-23-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,3,3 and 9 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 131339-23:
(8*1)+(7*3)+(6*1)+(5*3)+(4*3)+(3*9)+(2*2)+(1*3)=96
96 % 10 = 6
So 131339-23-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H30O3/c1-2-18-19(23-18)16-14-12-10-8-6-4-3-5-7-9-11-13-15-17-20(21)22/h3,5-6,8-9,11-12,14,18-19H,2,4,7,10,13,15-17H2,1H3,(H,21,22)/b5-3+,8-6+,11-9+,14-12+
131339-23-6Relevant articles and documents
DERIVATIVES OF EPA ENDOCANNABINOID EPOXIDES AS ANTI-INFLAMMATORY, ANTI-CANCEROUS, ANTI-ANGIOGENC AND ANTIPLATELET AGGREGATION COMPOUNDS
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Paragraph 00123, (2019/04/16)
The present disclosure provides chemical compound derivatives of a class of biological lipid mediators known as endocannabinoids and methods of synthesizing the compositions. These compounds are useful for treating cancer, reducing inflammation, reducing platelet aggregation, and reducing angiogenesis.
Enzymatic synthesis and chemical inversion provide both enantiomers of bioactive epoxydocosapentaenoic acids
Cinelli, Maris A.,Yang, Jun,Scharmen, Amy,Woodman, Joey,Karchalla, Lalitha M.,Lee, Kin Sing Stephen
, p. 2237 - 2252 (2018/11/30)
Epoxy PUFAs are endogenous cytochrome P450 (P450) metabolites of dietary PUFAs. Although these metabolites exert numerous biological effects, attempts to study their complex biology have been hampered by difficulty in obtaining the epoxides as pure regioi
Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450
Lucas, Daniele,Goulitquer, Sophie,Marienhagen, Jan,Fer, Maude,Dreano, Yvonne,Schwaneberg, Ulrich,Amet, Yolande,Corcos, Laurent
experimental part, p. 1125 - 1133 (2010/09/16)
Cytochromes P450 (CYPs) metabolize polyun-saturated long-chain fatty acids (PUFA-LC) to several classes of oxygenated metabolites. Through use of human recombinant CYPs, we recently showed that CYP1A1, -2C19, -2D6, -2E1, and -3A4 are mainly hydroxylases, whereas CYP1A2, -2C8, -2C9, and -2J2 are mainly epoxygenases of arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), respectively. It is worth noting that the last double bond of these PUFAs, i.e., ω6 in AA or ω3 in EPA and DHA, respectively, was preferentially epoxidized. In this study, we have characterized the stereoselectivity of this epoxidation reaction by comparison with the PUFA-LC epoxide stereoisomers obtained from the enantioselective bacterial CYP102A1 F87V. The stereoselectivity of the epoxidation of the last olefi n of AA (ω6), EPA (ω3), or DHA (ω3) differed between the CYP isoforms but was similar for EPA and DHA. These data give additional insight into the PUFA-LC epoxide enantiomers generated by the hepatic CYPs. Copyright
