1313429-35-4

Basic information

• Product Name: (3R,2S)-3-(3-methoxy-phenyl)-2-methyl-pentanoic acid
• Synonyms: (3R,2S)-3-(3-methoxy-phenyl)-2-methyl-pentanoic acid
• CAS NO: 1313429-35-4
• Molecular Weight: 222.284
• Mol File: 1313429-35-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3R,2S)-3-(3-methoxy-phenyl)-2-methyl-pentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,2S)-3-(3-methoxy-phenyl)-2-methyl-pentanoic acid(1313429-35-4)
• EPA Substance Registry System: (3R,2S)-3-(3-methoxy-phenyl)-2-methyl-pentanoic acid(1313429-35-4)

Safety Data

• Hazardous Substances Data: 1313429-35-4(Hazardous Substances Data)

Upstream product

• 1616-63-3 3-hydroxy-3-(3-methoxy-phenyl)-2-methyl-pentanoic acid ethyl ester 
• 1404478-78-9 3-(3-methoxy-phenyl)-2-methyl-pent-3-enoic acid ethyl ester 
• 13103-80-5 1-(3-hydroxyphenyl)propan-1-one 
• 37951-49-8 1-(3-methoxyphenyl)propan-1-one 

Relevant articles and documents

A NOVEL PROCESS FOR THE PREPARATION OF TAPENTADOL OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

Disclosed herein is a novel, commercially viable and industrially advantageous process for the preparation of 3-[(1R,2R))-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol (Tapentadol), or a pharmaceutically acceptable salt thereof, in high yield and purity. Also described are novel intermediates useful for preparing tapentadol or a pharmaceutically acceptable salt thereof.

PROCESS FOR THE PREPARATION OF L-PHENYL-3-DIMETHYLAMINOPROPANE DERIVATIVES

The present invention provides a process for the preparation of 1-phenyl-3-dimethylaminopropane derivatives of formula I, and its pharmaceutically acceptable salts thereof from intermediate of formula II, wherein R1 can be selected from -OR2, halo, -CH2OR2, -SR2, SOR2, SO2R2, -SO3H, -NO2, -NR2R2', - CONR2R2 ', carboxylic esters, sulfonate esters or phosphate esters and the like; R ' can be selected from hydrogen, alkyl, aryl, aralkyl, alkaryl, heteroaryl, and the like; or OR ' can be selected from -NR2R2 '; or R2 and R2 ' can be same or different and can be selected from hydrogen, alkyl, aryl, aralkyl, heteroaryl,-OR3, - COR3, -PO3(R3R4) wherein R3 and R4 can be same or different and can be selected from alkyl, aryl, aralkyl, heteroaryl and the like.