13135-69-8

Basic information

• Product Name: L-Proline, 4-hydroxy-1-methyl-, methyl ester, trans- (9CI)
• Synonyms: L-Proline, 4-hydroxy-1-methyl-, methyl ester, trans- (9CI);(R)-1-Methyl-4-hydroxy-L-proline Methyl Ester
• CAS NO: 13135-69-8
• Molecular Formula: C₇H₁₃NO₃
• Molecular Weight: 159.18302
• Product Categories: PYRROLE
• Mol File: 13135-69-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 53-54 °C
• Boiling Point: 102 °C
• Appearance: /
• Density: 1.184±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.48±0.40(Predicted)
• CAS DataBase Reference: L-Proline, 4-hydroxy-1-methyl-, methyl ester, trans- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, 4-hydroxy-1-methyl-, methyl ester, trans- (9CI)(13135-69-8)
• EPA Substance Registry System: L-Proline, 4-hydroxy-1-methyl-, methyl ester, trans- (9CI)(13135-69-8)

Safety Data

• Hazardous Substances Data: 13135-69-8(Hazardous Substances Data)

Usage

General Description

L-Proline, 4-hydroxy-1-methyl-, methyl ester, trans- (9CI) is a chemical compound with the molecular formula C6H11NO3. It is a trans isomer of 4-hydroxy-L-proline, which is an amino acid derivative found in certain proteins. This chemical has potential applications in the pharmaceutical industry, particularly in the development of new drugs and medications. Its trans configuration gives it unique properties that could be beneficial in various medical and scientific applications. Additionally, it may also have uses in chemical synthesis and research.

Upstream product

• 114358-11-1 (2S,4R)-2-methoxycarbonyl-4-hydroxypyrrolidine acetate 
• 51-35-4 4R-4-hydroxyproline 
• 50-00-0 formaldehyd 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 67-56-1 methanol 
• 4252-82-8 (2S, 4R)-4-hydroxy-1-methyl-2-pyrrolidinecarboxylic acid 

Downstream Products

• 1269662-81-8 (E)-3-[(2S,4R)-4-(tert-butyl(dimethyl)silyl)oxy-1-methylpyrrolidin-2-yl]-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolyl]prop-2-enoylamine 
• 1269662-71-6 (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2S,4R)-4-hydroxy-1-methyl-pyrrolidin-2-yl]propan-2-enoylamine 

Relevant articles and documents

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6-AMINO QUINAZOLINE OR 3-CYANO QUINOLINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF

6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof are disclosed. Specifically, the present disclosure discloses novel 6-amino quinazoline or 3-cyano quinoline derivatives presented by general formula (I), or tautomers, enantiomers, diastereomers, racemates or pharmaceutically acceptable salts thereof, or metabolites, metabolic precursors or prodrugs thereof, and their uses as treatment agents especially as protein kinase inhibitors, in which each substitutent group of general formula (I) is as defined in the specification.

Synthese optisch aktiver neungliedriger Lactame durch zwitterionische Aza-Claisen-Reaktion

Stichworte: Aza-Claisen-Reaktion * Azoninone * Chiralitaetstransfer * Lactame