1313530-07-2Relevant articles and documents
Rapid synthesis of diversely functionalized 3,4,7-trisubstituted indoles
Grant, Seth W.,Gallagher, Timothy F.,Bobko, Mark A.,Duquenne, Celine,Axten, Jeffrey M.
, p. 3376 - 3378 (2011/06/28)
Synthetic approaches are described for the synthesis of 4-alkoxyindole-7-carboxamides and 4-alkoxy-3-cyanoindole-7-carboxamides, which are useful intermediates in medicinal chemistry research. Two strategies were employed, highlighted by a Bartoli indole synthesis or a sequential and regioselective use of chlorosulfonyl isocyanate to install both the 3-cyano and 7-carboxamido groups. These routes are scalable and afford diversely functionalized indoles for further elaboration.