1313733-72-0Relevant articles and documents
Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate reductoisomerase
Andaloussi, Mounir,Henriksson, Lena M.,Wi?ckowska, Anna,Lindh, Martin,Bj?rkelid, Christofer,Larsson, Anna M.,Suresh, Surisetti,Iyer, Harini,Srinivasa, Bachally R.,Bergfors, Terese,Unge, Torsten,Mowbray, Sherry L.,Larhed, Mats,Jones, T. Alwyn,Karlén, Anders
, p. 4964 - 4976 (2011/10/01)
The natural antibiotic fosmidomycin acts via inhibition of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR), an essential enzyme in the non-mevalonate pathway of isoprenoid biosynthesis. Fosmidomycin is active on Mycobacterium tuberculosis DXR (MtDXR