1313876-82-2

Basic information

• Product Name: C₂₂H₂₇NO₂S₂
• Synonyms: C₂₂H₂₇NO₂S₂
• CAS NO: 1313876-82-2
• Molecular Weight: 401.594
• Mol File: 1313876-82-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₇NO₂S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₇NO₂S₂(1313876-82-2)
• EPA Substance Registry System: C₂₂H₂₇NO₂S₂(1313876-82-2)

Safety Data

• Hazardous Substances Data: 1313876-82-2(Hazardous Substances Data)

Upstream product

• 88255-11-2 p-(n-octyl)benzyl bromide 
• 1313876-80-0 C₂₂H₂₇NS₂ 

Downstream Products

• 1313876-85-5 2,2-dimethyl-5-[2-(4-octylphenyl)ethyl]-1,3-dioxan-5-amine 
• 1313876-84-4 5-(N-Cbz-amino)-5-[2-(4-octyloxyphenyl)ethenyl]-2,2-dimethyl-1,3-dioxane 

Relevant articles and documents

NOVEL PROCESS FOR SYNTHESIZING FINGOLIMOD HYDROCHLORIDE

The invention discloses a new synthetic route of Fingolimod hydrochloride, which includes the following steps: step1, reacting compound (5) with sulfhydryl compounds 1 under alkaline conditions, and obtaining key intermediate compound (6), step2, obtaining sulfone compound 7 through oxidation reaction of compound 6, step3, obtaining key intermediate compound (9) through Knoevenagel condensation reaction of the sulfone compound (7) and raw materials (aldehyde compound 8) under alkaline conditions, step4, obtaining 5- amino - 5 - [2 - (4 - N-octyl phenyl) ethyl ] - 2,2- two methyl - 1,3- two oxygen six ring through hydrogenation reduction reaction and deaminate protection of compound (9); then removing acetonide protection in the dilute hydrochloric acid solution, obtaining hydrochloride at the same time, hence getting the target compound (1) of Fingolimod hydrochloride. The advantage of the route of synthetic are as follows: the raw materials are cheap and easily obtained, and are easily to treat after reaction. It is not only to the safety of the experiment and high yield but also to reduce the pollution of the environment.