1314005-13-4Relevant articles and documents
Investigation into drug release from colon-specific azoreductase-activated steroid prodrugs using in-vitro models
Ruiz, Juan F. Marquez,Kedziora, Kinga,Windle, Henry,Kelleher, Dermot P.,Gilmer, John F.
experimental part, p. 806 - 816 (2012/04/10)
Objectives The aim of this study was to investigate drug release from a double steroid prodrug, OPN501, which incorporates a phenylpropionate linker, and its phenylacetate analogue. The prodrugs, which were designed to deliver prednisolone to the colon fo