1314228-13-1Relevant articles and documents
Design and synthesis of protein kinase Cα activators based on 'out of pocket' interactions
Hirai, Go,Ohkubo, Megumi,Tamura, Yuki,Sodeoka, Mikiko
, p. 3587 - 3590 (2011/08/06)
Novel types of PKCα activators based on isobenzofuranone bearing a myo-inositol moiety were designed and synthesized. The derivatives with bulky substituents on the myo-inositol moiety significantly activated PKCα, but their binding sites were not the same as that of phorbol ester.