1314254-42-6Relevant articles and documents
Pyridazine-derived γ-secretase modulators
Wan, Zehong,Hall, Adrian,Jin, Yun,Xiang, Jia-Ning,Yang, Eric,Eatherton, Andrew,Smith, Beverley,Yang, Guang,Yu, Haihua,Wang, Ju,Ye, Liang,Lau, Lit-Fui,Yang, Ting,Mitchell, William,Cai, Wei,Zhang, Xiaomin,Sang, Yingxia,Wang, Yonghui,Tong, Zhaolong,Cheng, Ziqiang,Hussain, Ishrut,Elliott, John D.,Matsuoka, Yasuji
, p. 4016 - 4019 (2011/08/06)
SAR of a novel series of pyridazine-derived γ-secretase modulators is described. Compound 25 was found to be a potent modulator in vitro, which on further profiling, was found to decrease Aβ42 and Aβ40, and maintain the levels of total Aβ. Furthermore, 25