1314747-02-8

Basic information

• Product Name: 3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-yl)phenol
• Synonyms: 3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-yl)phenol
• CAS NO: 1314747-02-8
• Molecular Weight: 312.679
• Mol File: 1314747-02-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-yl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-yl)phenol(1314747-02-8)
• EPA Substance Registry System: 3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-yl)phenol(1314747-02-8)

Safety Data

• Hazardous Substances Data: 1314747-02-8(Hazardous Substances Data)

Upstream product

• 121-71-1 3-Hydroxyacetophenone 
• 2454-35-5 3-acetylphenyl acetate 
• 1314746-84-3 3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-yl)phenyl acetate 
• 38396-89-3 2-bromo-3-acetyloxylacetophenone 
• 79456-26-1 2-amino-3-chloro-5-(trifluoromethyl)pyridine 
• 5000-65-7 2-bromo-3'-methoxyacetophenone 
• 1314747-01-7 C₁₅H₁₀ClF₃N₂O 

Downstream Products

• 1314746-84-3 3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-yl)phenyl acetate 
• 1477503-60-8 1-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenoxy)propan-2-one 
• 1477503-61-9 3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenyl methanesulfonate 
• 1477503-62-0 3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-methylbenzenesulfonate 

Relevant articles and documents

Synthesis and biological evaluation of glucagon-like peptide-1 receptor agonists

In this study, a series of fused-heterocyclic derivatives were systematically designed and synthesized using an efficient route, and evaluated in terms of GLP-1R agonist activity. We employed short synthetic steps and reactions that are tolerant of the presence of various functional groups and suitable for parallel operations to enable the rapid generation of libraries of diverse and structurally complex small molecules. Of the compounds synthesized, 3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a] pyridin-2-yl)phenyl methanesulfonate (8e) was the most potent agonist with an EC50 of 7.89 μM, and thus is the compound with the greatest potential for application. These findings represent a valuable starting point for the design and discovery of small-molecule GLP-1R agonists that can be administered orally.