1315267-73-2

Basic information

• Product Name: benzyl 5-bromo-2-[(4-fluorophenyl)ethynyl]phenylcarbamate
• Synonyms: benzyl 5-bromo-2-[(4-fluorophenyl)ethynyl]phenylcarbamate
• CAS NO: 1315267-73-2
• Molecular Weight: 424.269
• Mol File: 1315267-73-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: benzyl 5-bromo-2-[(4-fluorophenyl)ethynyl]phenylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 5-bromo-2-[(4-fluorophenyl)ethynyl]phenylcarbamate(1315267-73-2)
• EPA Substance Registry System: benzyl 5-bromo-2-[(4-fluorophenyl)ethynyl]phenylcarbamate(1315267-73-2)

Safety Data

• Hazardous Substances Data: 1315267-73-2(Hazardous Substances Data)

Upstream product

• 21740-00-1 5-bromo-2-iodo-benzoic acid 
• 88-67-5 2-Iodobenzoic acid 
• 1261850-57-0 C₇H₃BrINO 
• 293738-03-1 5-bromo-2-iodobenzoyl chloride 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 1315267-65-2 benzyl 5-bromo-2-iodophenylcarbamate 

Downstream Products

• 1315267-85-6 6-bromo-2-(4-fluorophenyl)-1H-indole 

Relevant articles and documents

Synthesis of 6-bromo-2-arylindoles using 2-iodobenzoic acid as precursor

The synthesis of 6-bromo-2-arylindoles starting from readily available 2-iodobenzoic acid is presented. Regioselective bromination of the latter was followed by Curtius rearrangement and trapping of the isocyanate with benzyl alcohol led to the benzyl carbamate of 2-iodo-5-bromoaniline. Chemoselective Sonogashira coupling of this compound with arylacetylenes followed by TBAF induced 5-endo-dig cyclization gave the desired bromo indoles. The method allows selective introduction of a bromine atom at the indole C-6 position.