131543-23-2 Usage
Description
WIN 55,212-2 MESYLATE, a member of the aminoalkylindole class of compounds, is a potent aminoalkylindole cannabinoid (CB) receptor agonist with high affinity for both human recombinant CB1 and CB2 receptors. It is known for its ability to modulate extracellular glutamate levels and induce the release of the proinflammatory neuropeptide CGRP from trigeminal ganglion neurons in a calcium-dependent manner.
Uses
Used in Pharmaceutical Research:
WIN 55,212-2 MESYLATE is used as a high affinity cannabinoid agonist for intraperitoneal injection into rats to induce behavioral sensitization. This application aids in understanding the effects of cannabinoid agonists on behavior and their potential therapeutic applications.
Used in Neuroscientific Studies:
WIN 55,212-2 MESYLATE is used as a synthetic cannabinoid drug and cannabinoid receptor 1 (CNR1) agonist to treat Becn2+/? mice and wild-type (WT) littermates. This application helps in analyzing the levels of CNR1 in the brain, which can provide insights into the role of cannabinoid receptors in neurological processes and disorders.
Used in Drug Delivery Systems:
Although not explicitly mentioned in the provided materials, WIN 55,212-2 MESYLATE could potentially be used in drug delivery systems to improve the delivery, bioavailability, and therapeutic outcomes of cannabinoid-based treatments. This application would involve the development of novel drug delivery systems, such as organic and metallic nanoparticles, to enhance the efficacy of WIN 55,212-2 MESYLATE against specific conditions or diseases.
Biological Activity
Nanomolar affinity cannabinoid receptor agonist (K i values are 62.3 and 3.3 nM at the human cloned CB 1 and CB 2 receptors respectively). Also available as part of the Cannabinoid Receptor Agonist Tocriset? .
Biochem/physiol Actions
It is known to decrease the lipopolysaccharide mediated release of tumor necrosis factor- α and interleukin-1 in mice.
References
1) Felder?et al. (1995),?Comparison of the pharmacology and signal transduction of the human cannabinoid CB1?and CB2receptors; Mol. Pharmacol.,?48?443
2) Herzberg?et al. (1997),?The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist in a rat model of neuropathic pain; Neurosci. Lett.,?221?157
3) Bouaboula?et al. (1995),?Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1; Biochem. J.,?312?637
Check Digit Verification of cas no
The CAS Registry Mumber 131543-23-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,5,4 and 3 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 131543-23:
(8*1)+(7*3)+(6*1)+(5*5)+(4*4)+(3*3)+(2*2)+(1*3)=92
92 % 10 = 2
So 131543-23-2 is a valid CAS Registry Number.
InChI:InChI=1/C27H26N2O3.CH4O3S/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28;1-5(2,3)4/h2-11,20H,12-17H2,1H3;1H3,(H,2,3,4)/t20-;/m1./s1
