131589-16-7Relevant articles and documents
Synthesis of (-)-egenine (decumbensine) by asymmetric carbonyl addition
Rein,Gawley
, p. 3711 - 3714 (1990)
The first synthesis of the phthalideisoquinoline hemiacetal egenine is reported, along with spectral data suggesting that egenine and decumbensine are one and the same. These synthetic studies are part of a larger investigation into the face-selectivity of additions of chiral dipole-stabilized organometallics to aldehydes. The synthesis of egenine and the correlation to bicuculline diol established the absolute configuration of the major stereoisomer formed as being opposite to that expected based on earlier work.