13161-30-3

Basic information

• Product Name: 2-Pyridinol-1-oxide
• Synonyms: Pyridinium,1,2-dihydroxy-,1-hydroxide,inner salt;2-Hydorxy Pyridine-N-Oxide;2-HYDROXYPYRIDINE N-OXIDE 98%;2-HYDROXYPYRIDINE N-OXIDE 98+%;2-HYDROXYPRIDINE-N-OXIDE;2-Hydroxypyridine-N-oxide, 2-Pyridinol N-oxide, 1-Hydroxy-2-pyridone;HPNO;1-Hydroxy-2-pyridone, 2-Pyridinol N-oxide
• CAS NO: 13161-30-3
• Molecular Formula: C₅H₅NO₂
• Molecular Weight: 111.1
• EINECS: 236-100-8
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;Other Products;Heterocycle-Pyridine series;Pharm intermediate
• Mol File: 13161-30-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 149-152 °C(lit.)
• Boiling Point: 387.694 °C at 760 mmHg
• Flash Point: 100 °C
• Appearance: /
• Density: 1.111
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: Store at RT.
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• PKA: pK1:-0.62;pK2:5.97(0) (25°C)
• Water Solubility: 331g/L
• BRN: 1422545
• CAS DataBase Reference: 2-Pyridinol-1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinol-1-oxide(13161-30-3)
• EPA Substance Registry System: 2-Pyridinol-1-oxide(13161-30-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-40
• Safety Statements: 26-36-22
• WGK Germany: 3
• Hazardous Substances Data: 13161-30-3(Hazardous Substances Data)

Usage

Description

2-Pyridinol-1-oxide (HOPO) is a versatile organic compound that serves as a peptide coupling agent and can form stable chelate complexes with transition metal ions. It is related to aspergillic acid and is derived from pyridine-N-oxide. With its bactericidal properties and ability to create chelates, 2-Pyridinol-1-oxide has found applications in various fields.

Uses

Used in Electrochemistry:
2-Pyridinol-1-oxide is used as a component in the fabrication of gold electrodes for the electrochemical determination of europium using cyclic voltammetry. Its ability to form stable chelates with metal ions makes it suitable for enhancing the selectivity and sensitivity of the electrochemical detection process.
Used in Polymer Chemistry:
In the field of polymer chemistry, 2-Pyridinol-1-oxide is used in the preparation of polymeric nickel (II) complexes of 2-hydroxypyridine-N-oxide. These complexes exhibit unique properties and can be utilized in various applications, such as catalysis and material science.
Used in Organic Synthesis:
2-Pyridinol-1-oxide plays a crucial role in the synthesis of 1-methoxypyrid-4-one, a key intermediate in the production of various pharmaceuticals and agrochemicals. The synthesis process involves the use of sodium methoxide and methyl toluene-9-sulphonate, highlighting the compound's reactivity and utility in organic synthesis.
Used as a Peptide Coupling Agent:
As a substitute for HOBt, 2-Pyridinol-1-oxide (HOPO) is used as a peptide coupling agent in the synthesis of peptides and proteins. Its ability to form stable chelates with transition metal ions aids in the efficient formation of peptide bonds, making it a valuable tool in the field of biochemistry and pharmaceutical development.
Used in Bactericidal Applications:
2-Pyridinol-1-oxide is also employed as a bactericidal agent due to its relationship with aspergillic acid. This property makes it useful in various applications, such as disinfectants, sanitizers, and preservatives, where controlling bacterial growth is essential.

InChI:InChI=1/C5H5NO2/c7-5-3-1-2-4-6(5)8/h1-4,7H

Synthetic route

2-hydroxypyridin (142-08-5) → 2-hydroxy-pyridine N-oxide (13161-30-3)

Conditions	Yield
With titanium silicate; dihydrogen peroxide In methanol at 60℃; for 25h; Oxidation;	92%
With oxygen; ruthenium trichloride In 1,2-dichloro-ethane at 20℃; under 760 Torr; for 12h;	52%
With Perbenzoic acid In 1,4-dioxane; water at 20℃; Thermodynamic data; Kinetics; Mechanism; other temp. (25, 30, 35 deg C); ΔS(excit.);

2,2-dimethyl-4-(2-oxo-1H-pyrid-1-yl)oxy-2H-1,3-benzoxazine (74405-16-6) → 2-hydroxy-pyridine N-oxide (13161-30-3) + salicylamide

Conditions	Yield
With hydrogenchloride for 3h; Product distribution; Ambient temperature;	A 90% B n/a

N-oxy-2-pyridyl phenacyl sulfoxide (65332-95-8) + 2,3-dimethyl-buta-1,3-diene (513-81-5) → 2-hydroxy-pyridine N-oxide (13161-30-3) + 2-Benzoyl-3,6-dihydro-4,5-dimethyl-2H-thiopyran (80738-10-9)

Conditions	Yield
In 1,4-dioxane at 100℃; for 24h; Yields of byproduct given;	A n/a B 85%

2-methoxypyridine N-oxide (20773-98-2) → 2-hydroxy-pyridine N-oxide (13161-30-3)

Conditions	Yield
With hydrogenchloride; water at 90 - 100℃; for 16h;	54%
With hydrogenchloride Heating;

pyridine N-oxide (694-59-7) → 3-hydroxypyridine N-oxide (6602-28-4) + 4-hydroxypyridine N-oxide (6890-62-6) + 2-hydroxy-pyridine N-oxide (13161-30-3)

Conditions	Yield
With water; hexachloroiridate(IV); dinitrogen monoxide Rate constant; Irradiation;

N-oxy-2-pyridyl phenacyl sulfoxide (65332-95-8) → 2-hydroxy-pyridine N-oxide (13161-30-3) + 2-Benzoyl-3,6-dihydro-4,5-dimethyl-2H-thiopyran (80738-10-9)

Conditions	Yield
With 2,3-dimethyl-buta-1,3-diene In 1,4-dioxane at 100℃; for 24h; Title compound not separated from byproducts;	A 98 % Spectr. B 99 % Spectr.

2-methoxypyridine (1628-89-3) → 2-hydroxy-pyridine N-oxide (13161-30-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: AcOH; H2O2 2: aq. HCl / Heating View Scheme

2-chloropyridine (109-09-1) → 2-hydroxy-pyridine N-oxide (13161-30-3)

Conditions	Yield
Multi-step reaction with 3 steps 1: 60 percent / MCPBA / CHCl3 / 24 h / 65 - 70 °C 2: 50 percent / NaOMe / 1 h / Heating 3: 54 percent / HCl, H2O / 16 h / 90 - 100 °C View Scheme

2-chloropyridine-N-oxide (2402-95-1) → 2-hydroxy-pyridine N-oxide (13161-30-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: 50 percent / NaOMe / 1 h / Heating 2: 54 percent / HCl, H2O / 16 h / 90 - 100 °C View Scheme

2-oxopyridin-1(2H)-yl 4-nitrobenzenesulfonate (1259401-62-1) → 2-hydroxy-pyridine N-oxide (13161-30-3)

Conditions	Yield
With dihydrogen peroxide In N-(2-hydroxyethyl)piperazine-N-(2-hydroxyethyl)piperazine-N'-ethanesulfonic acid pH=7.5;

2-oxopyridin-1(2H)-yl 2,4-dinitrobenzenesulfonate (1259401-63-2) → 2-hydroxy-pyridine N-oxide (13161-30-3)

Conditions	Yield
With dihydrogen peroxide In N-(2-hydroxyethyl)piperazine-N-(2-hydroxyethyl)piperazine-N'-ethanesulfonic acid pH=7.5;

4-(((2-oxopyridin-1(2H)-yl)oxy)sulfonyl)benzoic acid (1259401-64-3) → 2-hydroxy-pyridine N-oxide (13161-30-3)

Conditions	Yield
With dihydrogen peroxide In N-(2-hydroxyethyl)piperazine-N-(2-hydroxyethyl)piperazine-N'-ethanesulfonic acid pH=7.5; Kinetics;
With dihydrogen peroxide at 20℃; pH=7.5; Kinetics; HEPES buffer;

2-oxopyridin-1(2H)-yl benzenesulfonate (5033-19-2) → 2-hydroxy-pyridine N-oxide (13161-30-3)

Conditions	Yield
With dihydrogen peroxide In N-(2-hydroxyethyl)piperazine-N-(2-hydroxyethyl)piperazine-N'-ethanesulfonic acid pH=7.5; Kinetics;
With dihydrogen peroxide at 20℃; pH=7.5; Kinetics; HEPES buffer;

2-oxopyridin-1(2H)-yl 4-methylbenzene sulfonate (5087-06-9) → 2-hydroxy-pyridine N-oxide (13161-30-3)

Conditions	Yield
With dihydrogen peroxide In N-(2-hydroxyethyl)piperazine-N-(2-hydroxyethyl)piperazine-N'-ethanesulfonic acid pH=7.5; Kinetics;
With dihydrogen peroxide at 20℃; pH=7.5; Kinetics; HEPES buffer;

4-(((2-oxopyridin-1(2H)-yl)oxy)methyl)phenylboronic acid (1325206-84-5) → 2-hydroxy-pyridine N-oxide (13161-30-3)

Conditions	Yield
With dihydrogen peroxide at 20℃; pH=7.5; Kinetics; HEPES buffer;

1-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)pyridin-2(1H)-one (1254765-78-0) → 2-hydroxy-pyridine N-oxide (13161-30-3)

Conditions	Yield
With dihydrogen peroxide at 20℃; pH=7.5; Kinetics; HEPES buffer;

2-hydroxy-pyridine N-oxide (13161-30-3) → 2-hydroxypyridin (142-08-5)

Conditions	Yield
With triphenylphosphine; N-fused tetraphenylporphyrin rhenium(VII) trioxide In dichloromethane at 23℃; for 3h;	99%
With carbon dioxide; water; iron at 100℃; for 10h; Autoclave; Green chemistry; chemoselective reaction;	99%
With ammonium formate; silica gel; zinc In methanol at 20℃; for 0.166667h; chemoselective reaction;	91%

2-hydroxy-pyridine N-oxide (13161-30-3) → 5-aminopentanal hydrochloride

Conditions	Yield
Stage #1: 2-hydroxy-pyridine N-oxide With ammonium formate; 10percent palladium on carbon In methanol Heating; Stage #2: With hydrogenchloride In methanol Further stages.;	98%

2-hydroxy-pyridine N-oxide (13161-30-3) + ammonium tetraphenylborate (14637-34-4) → 2,2-diphenyl-1,3-dioxa-3a-azonia-2-borataindan

Conditions	Yield
In toluene byproducts: NH3, C6H6; soln. of B compd. and ligand refluxed for 15 h; filtered, filtrate evapd. to dryness, recrystd. from EtOH; elem. anal.;	93%

2-hydroxy-pyridine N-oxide (13161-30-3) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → 2-oxopyridin-1(2H)-yl 4-nitrobenzenesulfonate (1259401-62-1)

Conditions	Yield
With pyridine at 20℃; Inert atmosphere;	92%

2-hydroxy-pyridine N-oxide (13161-30-3) + 1,1,1,3,3,3-hexachloro-propan-2-one (116-16-5) → 1,1'-carbonyldioxydi[2(1H)-pyridone]

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 24h;	91%

2-hydroxy-pyridine N-oxide (13161-30-3) + gallium(III) nitrate hydrate → Ga(3+)*3C5H4NO2(1-)

Conditions	Yield
With sodium hydroxide In water pH=7;	90%

2-hydroxy-pyridine N-oxide (13161-30-3) + 4,7-Dichloro-2,2-dimethyl-2H-benzo[e][1,3]oxazine (81415-92-1) → 1-(7-Chloro-2,2-dimethyl-2H-benzo[e][1,3]oxazin-4-yloxy)-1H-pyridin-2-one (81416-09-3)

Conditions	Yield
With triethylamine In chloroform Heating;	89%

2-hydroxy-pyridine N-oxide (13161-30-3) + p-toluenesulfonyl chloride (98-59-9) → 2-oxopyridin-1(2H)-yl 4-methylbenzene sulfonate (5087-06-9)

Conditions	Yield
With pyridine at 20℃; Inert atmosphere;	89%

2-hydroxy-pyridine N-oxide (13161-30-3) + ammonium vanadate(V) + water (7732-18-5) → NH4[VO2(2-hydroxypyridine-N-oxide(-1H))2]*3H2O

Conditions	Yield
With acetic acid In ammonia; water aq. NH3; Sonication; aq. 25% NH3 soln. and H2O added to NH4VO3 and solid ligand; sonicated and heated gently; pH adjusted to 6.9-7.0 (aq. acetic acid); heated to boiling; cooled to room temp.; crystd. for 12 h; crystals collected; additional crystals obtained by slow evapn. of solvent; elem. anal.;	88.7%

2-hydroxy-pyridine N-oxide (13161-30-3) + 4-Chloro-2,2-diethyl-2H-benzo[e][1,3]oxazine (74405-11-1) → 1-(2,2-Diethyl-2H-benzo[e][1,3]oxazin-4-yloxy)-1H-pyridin-2-one (81416-05-9)

Conditions	Yield
With triethylamine In chloroform Heating;	88%

potassium hydridotris(3-phenylpyrazol-1-yl)borate + 2-hydroxy-pyridine N-oxide (13161-30-3) + copper(II) choride dihydrate → [Cu2(μ-Cl)2(2-hydroxypyridine-N-oxide(-H))2(3-phenylpyrazolyl)2]

Conditions	Yield
In dichloromethane soln. of 2-OH-pyridine N-oxide (0.104 mmol) in CH2Cl2 added dropwise to soln. of borate (0.104 mmol) and Cu salt (0.104 mmol) in CH2Cl2 under stirring, mixt. stirred at room temp. for 16 h; ppt. removed by filtration, filtrate evapd. under vac., residue dissolved in CH2Cl2, recrystd. by diffusion of heptane into soln.; elem. anal.;	87%

2-hydroxy-pyridine N-oxide (13161-30-3) + 4-bromomethylphenylboronic acid pinacol ester (138500-85-3) → 1-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)pyridin-2(1H)-one (1254765-78-0)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; Inert atmosphere;	87%

2-hydroxy-pyridine N-oxide (13161-30-3) + 4-chloro-2,2-dimethyl-2H-benzo[e][1,3]oxazine (74405-07-5) → 2,2-dimethyl-4-(2-oxo-1H-pyrid-1-yl)oxy-2H-1,3-benzoxazine (74405-16-6)

Conditions	Yield
With triethylamine In chloroform Product distribution; Heating; reactions of several derivatives with var. pyridine N-oxides;	85%
With triethylamine In chloroform Heating;	85%

2-hydroxy-pyridine N-oxide (13161-30-3) + 2,2-dimethyl-4-chloro-6-methoxy-2H-1,3-benzoxazine (74405-14-4) → 1-(6-Methoxy-2,2-dimethyl-2H-benzo[e][1,3]oxazin-4-yloxy)-1H-pyridin-2-one (81416-08-2)

Conditions	Yield
With triethylamine In chloroform Heating;	85%

2-hydroxy-pyridine N-oxide (13161-30-3) + benzyl bromide (100-39-0) → 1-(benzyloxy)pyridin-2(1H)-one (5280-02-4)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 16h;	84%

2-hydroxy-pyridine N-oxide (13161-30-3) + nickel(II) chloride hexahydrate → Ni(2+)*2C5H4NO2(1-)

Conditions	Yield
In ethanol at 20℃; for 72h; Heating;	83%

2-hydroxy-pyridine N-oxide (13161-30-3) + 2-anthroic acid (613-08-1) → 1-(2-anthroyloxy)-2-pyridone (487010-91-3)

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane	82%

2-hydroxy-pyridine N-oxide (13161-30-3) + C13H14ClNO (74405-12-2) → C18H18N2O3 (81416-06-0)

Conditions	Yield
With triethylamine In chloroform Heating;	81%

2-hydroxy-pyridine N-oxide (13161-30-3) + 4,6-Dichloro-2,2-dimethyl-2H-benzo[e][1,3]oxazine (74405-13-3) → 1-(6-Chloro-2,2-dimethyl-2H-benzo[e][1,3]oxazin-4-yloxy)-1H-pyridin-2-one (81416-07-1)

Conditions	Yield
With triethylamine In chloroform Heating;	80%

2-hydroxy-pyridine N-oxide (13161-30-3) + anthracene-1-carboxylic acid (607-42-1) → 1-(1-anthroyloxy)-2-pyridone (487010-81-1)

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane	78%

2-hydroxy-pyridine N-oxide (13161-30-3) + [(9aneS3)Ru(dmso)3](PF6)2 → C13H22NO3RuS4(1+)*F6P(1-)

Conditions	Yield
With sodium methylate In methanol for 2h; Reflux;	78%

2-hydroxy-pyridine N-oxide (13161-30-3) + benzenesulfonyl chloride (98-09-9) → 2-oxopyridin-1(2H)-yl benzenesulfonate (5033-19-2)

Conditions	Yield
With pyridine at 20℃; Inert atmosphere;	77%
With pyridine at 20℃; Cooling with ice; Inert atmosphere;	77%

2-hydroxy-pyridine N-oxide (13161-30-3) + 9-Anthracenecarboxylic acid (723-62-6) → 1-(9-anthroyloxy)-2-pyridone

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane	72%

zinc(II) sulfate heptahydrate + 2-hydroxy-pyridine N-oxide (13161-30-3) → di(2-hydroxypyridine-N-oxidato)zinc(II)

Conditions	Yield
With Ba(OH)2*8H2O In water byproducts: BaSO4; to an aq. soln. of 2-hydroxypyridine-N-oxide and Ba(OH)2*8H2O an aq. soln. of ZnSO4*7H2O added followed by stirring for 5 h at room temp.; filtration of BaSO4, removal of solvent, residue dissolved with hot water and reprecipitated with methanol, washed with a small amts. of methanol, elem. anal.;	71%
With barium hydroxide octahydrate In water at 20℃;

2-hydroxy-pyridine N-oxide (13161-30-3) → 3-amino-6-hydroxy pyridine N-oxide (900139-09-5) + 5-nitro-2-hydroxypyridine-N-oxide (14396-03-3)

Conditions	Yield
With nitric acid In acetic acid	A n/a B 68%

2-hydroxy-pyridine N-oxide (13161-30-3) → 5-nitro-2-hydroxypyridine-N-oxide (14396-03-3)

Conditions	Yield
With nitric acid; acetic acid In water at 10 - 35℃; for 0.5h;	68%

2-hydroxy-pyridine N-oxide (13161-30-3) + 4-methoxy-1-naphthoic acid chloride (70696-57-0) → 1-(4-methoxy-1-naphthoyloxy)-2-pyridone (390755-08-5)

Conditions	Yield
With dmap In dichloromethane at 20℃;	67%

Upstream product

• 142-08-5 2-hydroxypyridin 
• 65332-95-8 N-oxy-2-pyridyl phenacyl sulfoxide 
• 1254765-78-0 1-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)pyridin-2(1H)-one 
• 1325206-84-5 4-(((2-oxopyridin-1(2H)-yl)oxy)methyl)phenylboronic acid 
• 5087-06-9 2-oxopyridin-1(2H)-yl 4-methylbenzene sulfonate 
• 5033-19-2 2-oxopyridin-1(2H)-yl benzenesulfonate 
• 1259401-64-3 4-(((2-oxopyridin-1(2H)-yl)oxy)sulfonyl)benzoic acid 
• 1259401-63-2 2-oxopyridin-1(2H)-yl 2,4-dinitrobenzenesulfonate 
• 1259401-62-1 2-oxopyridin-1(2H)-yl 4-nitrobenzenesulfonate 
• 2402-95-1 2-chloropyridine-N-oxide 
• 109-09-1 2-chloropyridine 
• 1628-89-3 2-methoxypyridine 
• 20773-98-2 2-methoxypyridine N-oxide 
• 513-81-5 2,3-dimethyl-buta-1,3-diene 

Downstream Products

• 142-08-5 2-Pyridone 
• 900139-09-5 5-amino-2-hydroxypyridine-N-oxide 
• 14396-03-3 5-nitro-2-hydroxypyridine-N-oxide 
• 5033-19-2 2-oxopyridin-1(2H)-yl benzenesulfonate 
• 1254765-78-0 1-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)pyridin-2(1H)-one 
• 1259401-63-2 2-oxopyridin-1(2H)-yl 2,4-dinitrobenzenesulfonate 
• 5087-06-9 2-oxopyridin-1(2H)-yl 4-methylbenzene sulfonate 
• 1259401-62-1 2-oxopyridin-1(2H)-yl 4-nitrobenzenesulfonate 
• 1259401-64-3 4-(((2-oxopyridin-1(2H)-yl)oxy)sulfonyl)benzoic acid 
• 5280-02-4 1-(benzyloxy)pyridin-2(1H)-one 
• 142-08-5 2-hydroxypyridin 

Relevant articles and documents

Pattern of Addition of Hydroxyl Radicals to the Spin Traps α-Pyridyl 1-Oxide N-tert-Butyl Nitrone

Hydroxyl radicals react with α-2, α-3, and α-4-pyridyl 1-oxide N-tert-butyl nitrones (POBN) with rate constants of 3.2E9, 4.8E9, and 3.5E9 M-1 s-1, respectively, via addition to two distinct sites.Addition to the pyridine ring yields short-lived radicals of the hydroxyazacyclohexadienyl type, while addition to the nitrone function in the side chain yields long-lived nitroxide radicals.The distribution of OH addition at the two molecular sites was determined by using differences in reducing power upon reaction of the different types of radicals with IrCl62-.The fraction of OH attack on the pyridine ring is ca. 0.6, relatively independent of the isomeric structure of the POBN.

Alkyl transfer with retention and inversion of configuration: Reexamination of a putative [1s,4s] sigmatropic rearrangement

The thermal rearrangement of 2-alkoxypyridine-1-oxides to 1-alkoxy-2-pyridones, which has been reported to proceed by an intramolecular [1s,4s] sigmatropic migration of the alkyl group with retention of configuration and first-order kinetics, has been reexamined. The intramolecular barriers have been computed to be at least 20 kcal mol-1 higher than the reported experimental barriers. An alternative bimolecular mechanism, discovered computationally, has been confirmed by a variety of experiments including crossover studies, determination of solvent effects and secondary H/D isotope effects, and new kinetic and stereochemical studies. In the new mechanism there is an initial intermolecular transfer of the alkyl group, with inversion of configuration, to the N-oxide. Depending on the nature of the alkyl group and the solvent, this is followed by a second transfer, also with inversion of configuration, of one of the alkyl groups of the cationic intermediate to one of the oxygens of the anionic intermediate. The product is then formed either without crossover, by a double inversion of one alkyl group, or with crossover by two single inversions of different alkyl groups. The proposed intermediates of this mechanism can be synthesized; they react to form a 1-alkoxy-2-pyridone at room temperature.

STIMULUS-TRIGGERED PRODRUGS

Set forth herein, inter alia, are compositions and methods for treating diseases with prodrugs. Provided herein are prodrug compositions for inhibiting the function of proteins, compositions and methods for treating diseases associated with oxidative compounds, oxidatively-sensitive prodrugs of inhibitors of metalloproteases. and methods of inhibiting metalloproteases using oxidatively-sensitive prodrugs.

An efficient synthesis of heterocyclic N-oxides over molecular sieve catalyst

Heterocyclic N-oxides have been synthesized in very high yields over redox molecular sieve catalysts in the presence of H2O2.