1316653-56-1

Basic information

• Product Name: 1-(3,4-dichlorophenyl)-5-(3,4-dimethoxymethylenephenyl)penta-2,4-dien-1-one
• CAS NO: 1316653-56-1
• Molecular Weight: 347.197
• Mol File: 1316653-56-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3,4-dichlorophenyl)-5-(3,4-dimethoxymethylenephenyl)penta-2,4-dien-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-dichlorophenyl)-5-(3,4-dimethoxymethylenephenyl)penta-2,4-dien-1-one(1316653-56-1)
• EPA Substance Registry System: 1-(3,4-dichlorophenyl)-5-(3,4-dimethoxymethylenephenyl)penta-2,4-dien-1-one(1316653-56-1)

Safety Data

• Hazardous Substances Data: 1316653-56-1(Hazardous Substances Data)

Upstream product

• 4043-71-4 isosafrole 
• 821775-38-6 3-(3′,4′-methylenedioxophenyl)propenal 
• 2642-63-9 3',4'-dichloroacetophenone 

Relevant articles and documents

Tandem allylic oxidation-condensation/esterification catalyzed by silica gel: An expeditious approach towards antimalarial diaryldienones and enones from natural methoxylated phenylpropenes

A new one-pot strategy has been developed, wherein abundantly available methoxylated phenylpropenes are directly transformed into corresponding dienones (1,5-diarylpenta-2,4-dien-1-ones) and enones (chalcones and cinnamic esters) via allylic oxidation-condensation or allylic oxidation-esterification sequences. Preliminary antimalarial activity studies of the above synthesized diaryldienones and enones against Plasmodium falciparum (Pf3D7) have shown them to be promising lead candidates for developing newer and economical antimalarial agents. In particular, two enones (12b and 13b) were found to possess comparatively better activity (IC50 = 4.0 and 3.4 μM, respectively) than licochalcone (IC50 = 4.1 μM), a well known natural antimalarial compound. The Royal Society of Chemistry 2011.