1316852-87-5Relevant articles and documents
Synthesis and antitumor activity of novel podophyllotoxin derivatives against multidrug-resistant cancer cells
Guo, Yong-En,Chen, Hong,Zuo, Song,Liu, Dai-Lin,Lu, Yan-Ling,Lv, Jing-Jing,Wen, Shao-Peng,Zhang, Tong-Cun
, p. 417 - 424 (2011/07/29)
Seven novel 4-N-substituted podophyllotoxin derivatives with indole rings were prepared and evaluated for cytotoxicity against human cancer cell lines HeLa, KB, KBV, K562, and K562/AO2. Most of them demonstrated improved antitumor activity and weak multidrug resistance compared to the drugs currently available.