1316889-29-8Relevant articles and documents
A hydrogen peroxide based access to qinghaosu (artemisinin)
Hao, Hong-Dong,Li, Yun,Han, Wei-Bo,Wu, Yikang
, p. 4212 - 4215 (2011)
Attachment of H2O2 onto the highly hindered quaternary C-12a in an advanced qinghaosu (artemisinin) precursor has been achieved through a facile perhydrolysis of a spiro epoxy ring with the aid of a previously unknown molybdenum species without involving any special equipment or complicated operations. The resultant β-hydroxyhydroperoxide can be further elaborated into qinghaosu, illustrating an entry fundamentally different from the existing ones to this outstanding natural product of great importance in malaria chemotherapy.