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131719-86-3

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131719-86-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 131719-86-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,7,1 and 9 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 131719-86:
(8*1)+(7*3)+(6*1)+(5*7)+(4*1)+(3*9)+(2*8)+(1*6)=123
123 % 10 = 3
So 131719-86-3 is a valid CAS Registry Number.

131719-86-3Relevant articles and documents

Total Synthesis of rapamycin

Ley, Steven V.,Tackett, Miles N.,Maddess, Matthew L.,Anderson, James C.,Brennan, Paul E.,Cappi, Michael W.,Heer, Jag P.,Helgen, Celine,Kori, Masakuni,Kouklovsky, Cyrille,Marsden, Stephen P.,Norman, Joanne,Osborn, David P.,Palomero, Maria A.,Pavey, John B. J.,Pinel, Catherine,Robinson, Lesley A.,Schnaubelt, Juergen,Scott, James S.,Spilling, Christopher D.,Watanabe, Hidenori,Wesson, Kieron E.,Willis, Michael C.

supporting information; experimental part, p. 2874 - 2914 (2009/12/25)

For over 30 years, rapamycin has generated a sustained and intense interest from the scientific community as a result of its exceptional pharmacological properties and challenging structural features. In addition to its well known therapeutic value as a potent immunosuppressive agent, rapamycin and its derivatives have recently gained prominence for the treatment of a wide variety of other human malignancies. Herein we disclose full details of our extensive investigation into the synthesis of rapamycin that culminated in a new and convergent preparation featuring a macro-etherification/catechol-templating strategy for construction of the macrocyclic core of this natural product.

DEGRADATIVE STUDIES ON THE TRICARBONYL CONTAINING MACROLIDE RAPAMYCIN

Goulet, Mark T.,Boger, Joshua

, p. 4845 - 4848 (2007/10/02)

The degradation of rapamycin, a tricarbonyl containing macrolide similar in structure to the potent immunosuppressant FK-506, is described.Three principal fragments are obtained in this process that should have utility in the semi-synthesis of FK-506 and

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