131722-62-8Relevant articles and documents
1,2,5,6-Diepoxyhexane and 1,2,7,8-diepoxyoctane cross-link duplex DNA at 5'-GNC sequences
Yunes, Michael J.,Charnecki, Sara E.,Marden, Jennifer J.,Millard, Julie T.
, p. 994 - 1000 (1996)
The carcinogenicity of epoxide compounds has been attributed to covalent binding to DNA. Whereas monoepoxides form only monoadducts, diepoxides can form both monoadducts and interstrand cross-links. The latter are believed to be the more significant cytotoxic lesions as diepoxides are frequently more carcinogenic and mutagenic than their monoepoxide analogues. We therefore examined the relative DNA interstrand cross-linking capabilities of several diepoxides with respect to chain length, molecular flexibility, reported carcinogenic potential, and DNA sequences targeted. Using denaturing polyacrylamide gel electrophoresis, we found that 1,2,5,6- diepoxyhexane and 1,2,7,8-diepoxyoctane share the 5'-GNC target sequence previously found for 1,2,3,4-diepoxybutane [Millard, J. T., and White, M. M. (1993) Biochemistry 32, 2120-2124] and that the efficiency of cross-linking this sequence may reflect carcinogenicity. 1,2,5,6-Diepoxycyclooctane, the biologically inactive rigid analogue of 1,2,5,6-diepoxyhexane, was found to be a poor cross-linker of all DNA sequences examined. Moreover, increasing the diepoxyalkane chain length did not result in enhanced cross-linking ability.
One-pot method for preparing diepoxide (by machine translation)
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Paragraph 0077-0084, (2020/05/01)
The method comprises the following steps, adding a reducing agent water solution :S1. to a reactor: slowly dropwise adding a reducing agent aqueous solution to obtain the diepoxide, adding a reducing agent aqueous solution to the reactor, to obtain the diepoxy, and separating and purifying ;S2. from the organic phase: by one-pot reaction, and adding a reducing agent water, through a pot method to obtain the diepoxide crude solution, to obtain the diepoxide compound. The invention discloses a method for separating and purifying a diepoxide crude product through a high vacuum, distillation . The method comprises the following steps of: adding a reducing agent aqueous solution to the, reactor at a low temperature, to obtain a diepoxide 91% crude, product through 95% a, one-pot reaction, of the diolefin and the m-chloroperoxybenzoic acid solution to obtain a diepoxide crude product solution. (by machine translation)
AMINOMETHYL- AND METHYLOXY-LINKED TRICYCLIC COMPOUNDS AS INHIBITORS OF PROTEIN AGGREGATION
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Paragraph 0085, (2016/06/01)
The present invention relates to certain aminomethyl- and methyloxy-linked tricyclic compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy.
Coordination of new disulfide ligands to CuIand CuII: Does a CuII μ-thiolate complex form?
Ording-Wenker, Erica C. M.,Siegler, Maxime A.,Bouwman, Elisabeth
supporting information, p. 193 - 202 (2015/03/04)
Interest in dinuclear CuII μ-thiolate and CuI disulfide complexes is triggered by their similarity with the CuA site and the possibility to control this redox equilibrium. Three new disulfide ligands L1, L3 and L4 were synthesized and reacted with CuI salts to investigate whether thiolate or disulfide species would form. The nature of L1 precludes the formation of CuII μ-thiolate species, resulting in the formation of [Cu2I(L1)(CH3CN)](BF4)2 which was characterized via single crystal X-ray crystallography. Pyrazole-containing ligands L3 and L4 form CuI complexes that are stable in solution in air for hours with half-wave potentials of approximately +0.55 V versus Ag/AgCl, indicating high stability of the CuI state rather than the CuII state. The half-wave potentials of the CuI complexes with L1 and L2 are less positive, indicating that in order to allow formation of both CuII μ-thiolate and CuI disulfide species, a half-wave potential of roughly 0 V versus Ag/AgCl would be ideal. Furthermore, CuII crystal structures with L1, L2, L3 and L4 and different counterions were compared and analyzed. Pyrazolyl-containing ligands L3 and L4 form complexes that are very similar to the complexes with pyridyl-containing ligands L1 and L2.
