131747-63-2 Usage
Description
4-BROMOPYRIDINE-2-CARBALDEHYDE is an organic compound with the molecular formula C6H4BrNO. It is a derivative of pyridine, featuring a bromo substituent at the 4-position and a formyl group (aldehyde) at the 2-position. 4-BROMOPYRIDINE-2-CARBALDEHYDE is known for its reactivity and is commonly utilized in the synthesis of various organic molecules, particularly in the pharmaceutical and chemical industries.
Uses
Used in Pharmaceutical Industry:
4-BROMOPYRIDINE-2-CARBALDEHYDE is used as a synthetic reagent for the production of Curcumin analogues. Curcumin, a natural compound derived from the turmeric plant, has been extensively studied for its anti-inflammatory, antioxidant, and anticancer properties. The analogues synthesized using 4-BROMOPYRIDINE-2-CARBALDEHYDE may exhibit similar or enhanced biological activities, making them valuable for the development of new drugs and therapies.
Used in Chemical Synthesis:
4-BROMOPYRIDINE-2-CARBALDEHYDE is also used as a key intermediate in the preparation of 1,4-dihydropyridine calcium antagonists. These compounds are important in the treatment of cardiovascular diseases, such as hypertension and angina, due to their ability to relax blood vessel walls and improve blood flow. The synthesis of these calcium antagonists often involves the use of 4-BROMOPYRIDINE-2-CARBALDEHYDE as a starting material or a building block in the chemical reactions.
Check Digit Verification of cas no
The CAS Registry Mumber 131747-63-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,7,4 and 7 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 131747-63:
(8*1)+(7*3)+(6*1)+(5*7)+(4*4)+(3*7)+(2*6)+(1*3)=122
122 % 10 = 2
So 131747-63-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H4BrNO/c7-5-1-2-8-6(3-5)4-9/h1-4H
131747-63-2Relevant articles and documents
INHIBITORS OF RAF KINASES
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Paragraph 00297; 00300-00301, (2022/04/03)
Provided herein are inhibitors of receptor tyrosine kinase effector, RAF, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.
ANALOGS OF 2-PRALIDOXIME AS ANTIDOTES AGAINST ORGANOPHOSPHORUS NERVE AGENTS
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Paragraph 0079, (2020/02/23)
Provided herein are compounds useful in treating exposure to an organophosphorus compound, such as a nerve agent, pesticide, or, generally, an acetylcholinesterase inhibitor, such as sarin. Compositions, e.g. pharmaceutical compositions or dosage forms, comprising the compounds also are provided herein. Methods of treating a patient exposed to a nerve agent, pesticide, or, generally, an acetylcholinesterase inhibitor, e.g., an organophosphorus compound, such as sarin, also are provided.
2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties
Charoensutthivarakul, Sitthivut,Hong, W. David,Leung, Suet C.,Gibbons, Peter D.,Bedingfield, Paul T.P.,Nixon, Gemma L.,Lawrenson, Alexandre S.,Berry, Neil G.,Ward, Stephen A.,Biagini, Giancarlo A.,O'Neill, Paul M.
supporting information, p. 1252 - 1259 (2015/07/15)
A series of 2-pyridylquinolones has been prepared in 5-7 steps and through lead optimisation, antimalarial activity as low as 12 nM against Plasmodium falciparum (Pf) has been achieved. Compared with previous analogues in this series, selected molecules h
