131747-65-4 Usage
Description
6-Trifluoromethyl-pyridine-2-carbaldehyde is an organic compound characterized by the presence of a trifluoromethyl group at the 6th position and a formyl group at the 2nd position on a pyridine ring. It is a valuable intermediate in the synthesis of various complex molecules and pharmaceuticals due to its unique structural features and reactivity.
Uses
Used in Pharmaceutical Industry:
6-Trifluoromethyl-pyridine-2-carbaldehyde is used as a key intermediate for the synthesis of [1,2,3]triazolo[1,5-a]pyridines, which are important classes of compounds with potential applications in the development of new drugs. These compounds exhibit a range of biological activities, including anti-cancer, anti-inflammatory, and anti-microbial properties.
Used in Chemical Synthesis:
6-Trifluoromethyl-pyridine-2-carbaldehyde is used as a versatile building block for the synthesis of various complex organic molecules, particularly those containing the trifluoromethyl and pyridine moieties. Its reactivity and stability make it a valuable component in the development of new materials and compounds with diverse applications.
Used in Medicinal Chemistry:
6-Trifluoromethyl-pyridine-2-carbaldehyde is used as a starting material for the development of triple T-type calcium channel blockers. These blockers are important in the treatment of various cardiovascular diseases, such as hypertension and angina, by selectively inhibiting the T-type calcium channels, which play a crucial role in the regulation of heart rate and blood pressure.
Check Digit Verification of cas no
The CAS Registry Mumber 131747-65-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,7,4 and 7 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 131747-65:
(8*1)+(7*3)+(6*1)+(5*7)+(4*4)+(3*7)+(2*6)+(1*5)=124
124 % 10 = 4
So 131747-65-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H4F3NO/c8-7(9,10)6-3-1-2-5(4-12)11-6/h1-4H
131747-65-4Relevant articles and documents
AROMATIC HETEROCYCLIC COMPOUND, INTERMEDIATE THEREOF, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
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Paragraph 0218; 0221-0222, (2021/02/05)
Disclosed are an aromatic heterocyclic compound, an intermediate thereof, a preparation method therefor, and a pharmaceutical composition and use thereof. The aromatic heterocyclic compound of the present invention is a new ALK5 inhibitor, and is used for treating and/or preventing various ALK5-mediated diseases.
NOVEL INDOLIZINE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
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Page/Page column 122; 123, (2020/11/12)
The present invention relates generally to novel antiviral agents. Specifically, the present invention relates to compounds which can inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV replication cycle, compositions comprising such compounds, methods for inhibiting HBV viral replication, methods for treating or preventing HBV infection, and processes and intermediates for making the compounds.
Novel 1,4-dihydropyridine calcium antagonists. I. Synthesis and hypotensive activity of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives
Ashimori,Ono,Uchida,Ohtaki,Fukaya,Watanabe,Yokoyama
, p. 2446 - 2458 (2007/10/02)
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