131864-67-0

Basic information

• Product Name: (R,R)-2,2'-(2,6-PYRIDINEDIYL)BIS(4-ISOPROPYL-2-OXAZOLINE)
• Synonyms: 2,6-bis((R)-4-isopropyl-4,5-dihydrooxazol-2-yl)pyridine;2,6-Bis[(4R)-(+)-isopropyl-2-oxazolin-2-yl]pyridine 99%;(+)-2,6-Bis[(4R)-4-(i-propyl)-2-oxazolin-2-yl]pyridine,97%;2,6-Bis[(4R)-isopropyl-2-oxazolin-2-yl]pyridine,99%e.e.;2,6-BIS[(4R)-(+)-ISOPROPYL-2-OXAZOLIN-2-YL]PYRIDINE;(+)-2,6-BIS[(4R)-4-(I-PROPYL)-2-OXAZOLIN-2-YL]PYRIDINE;(R,R)-2,6-BIS(4-ISOPROPYL-2-OXAZOLIN-2-YL)PYRIDINE;(R,R)-2,2'-(2,6-PYRIDINEDIYL)BIS(4-ISOPROPYL-2-OXAZOLINE)
• CAS NO: 131864-67-0
• Molecular Formula: C₁₇H₂₃N₃O₂
• Molecular Weight: 301.38
• Product Categories: Chiral Catalysts, Ligands, and Reagents;Privileged Ligands and Complexes;PyBOX;organic amine;BOX series;Chiral Nitrogen;Asymmetric Synthesis;Synthetic Organic Chemistry
• Mol File: 131864-67-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 154-156 °C(lit.)
• Boiling Point: 457.055 °C at 760 mmHg
• Flash Point: 230.219 °C
• Appearance: white/crystal
• Density: 1.233 g/cm³
• Vapor Pressure: 4.18E-08mmHg at 25°C
• Refractive Index: 118 ° (C=1, CH2Cl2)
• Storage Temp.: Refrigerator
• PKA: 3.78±0.70(Predicted)
• CAS DataBase Reference: (R,R)-2,2'-(2,6-PYRIDINEDIYL)BIS(4-ISOPROPYL-2-OXAZOLINE)(CAS DataBase Reference)
• NIST Chemistry Reference: (R,R)-2,2'-(2,6-PYRIDINEDIYL)BIS(4-ISOPROPYL-2-OXAZOLINE)(131864-67-0)
• EPA Substance Registry System: (R,R)-2,2'-(2,6-PYRIDINEDIYL)BIS(4-ISOPROPYL-2-OXAZOLINE)(131864-67-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 131864-67-0(Hazardous Substances Data)

Usage

Description

(R,R)-2,2'-(2,6-PYRIDINEDIYL)BIS(4-ISOPROPYL-2-OXAZOLINE) is a C2 symmetric ligand that is used in enantioselective catalysis. It is a white powder and is known for its strong affinity for various metals due to the oxazoline nitrogen, which allows it to easily form bidentate coordination complexes.

Uses

Used in Chemical Industry:
(R,R)-2,2'-(2,6-PYRIDINEDIYL)BIS(4-ISOPROPYL-2-OXAZOLINE) is used as a C2 symmetric ligand for enantioselective catalysis. Its strong affinity for various metals allows it to easily form bidentate coordination complexes, making it a valuable tool in the synthesis of chiral compounds.
Used in Pharmaceutical Industry:
(R,R)-2,2'-(2,6-PYRIDINEDIYL)BIS(4-ISOPROPYL-2-OXAZOLINE) is used as a chiral ligand in the development of enantioselective catalysts for the synthesis of pharmaceutical compounds. Its ability to form bidentate coordination complexes with various metals makes it a useful tool in creating chiral centers in drug molecules, which can improve the efficacy and selectivity of these compounds.

Reaction

Ligand for enantioselective nitrone cycloaddition to α,β-unsaturated 2-acyl imidazoles. Highly efficient catalytic enantioselective Mannich reaction of malonates with N-tert-butoxycarbonyl imines.

InChI:InChI=1/C17H23N3O2/c1-10(2)14-8-21-16(19-14)12-6-5-7-13(18-12)17-20-15(9-22-17)11(3)4/h5-7,10-11,14-15H,8-9H2,1-4H3/t14-,15-/m0/s1