131887-73-5

Basic information

• Product Name: 3,5-dichlorobenzyl carbamimidothioate
• Synonyms: 3,5-dichlorobenzyl carbamimidothioate
• CAS NO: 131887-73-5
• Molecular Weight: 235.137
• Mol File: 131887-73-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3,5-dichlorobenzyl carbamimidothioate(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dichlorobenzyl carbamimidothioate(131887-73-5)
• EPA Substance Registry System: 3,5-dichlorobenzyl carbamimidothioate(131887-73-5)

Safety Data

• Hazardous Substances Data: 131887-73-5(Hazardous Substances Data)

Upstream product

• 17356-08-0 thiourea 
• 3290-06-0 1,3-dichloro-5-chloromethyl-benzene 

Downstream Products

• 124879-99-8 (1R,2R)-2-(3,5-Dichloro-phenyl)-1-oxo-hexahydro-1λ⁴-thiopyran-2-carbothioic acid methylamide 
• 124880-25-7 2-(3,5-Dichloro-phenyl)-tetrahydro-thiopyran 1-oxide 
• 124880-28-0 (+/-)-1-[(4-chlorobutyl)sulphinylmethyl]-3,5-dichlorobenzene 
• 124880-30-4 1,3-Dichloro-5-(4-chloro-butylsulfanylmethyl)-benzene 
• 65963-17-9 (3,5-dichlorophenyl)methanethiol 

Relevant articles and documents

NTCP INHIBITORS

Provided are cyclosporin A analogues that are NTCP inhibitors and useful for treating HBV and/or HDV infection (s), hepatoprotection and amelioration of hypercholesterolemia, diabetes and inhibiting cancer.

Synthesis and Biological Activity of trans-(+/-)-N-Methyl-2-(3-pirydyl)-2-tetrahydrothiopyrancarbothioamide 1-Oxide (RP 49356) and Analogues: A New Class of Potassium Channel Opener

The synthesis and biological activity of trans-(+/-)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-oxide (8a, RP 49356) and analoques is reported.These compounds constitute a new structural class of K+-channel opener.The effects of changes in the pyridyl group, thioamide, and thiane ring on in vitro K+-channel opening activity are discussed.A 3-pyridyl or 3-quinolyl group, a small N-alkyl thioamide function, and a thiane oxide ring, in which the sulfoxide is in a trans relationship to thioamide, are preferred for activity.Selected compounds were tested intravenously in the normotensive anaesthetized rat for hypotensive effects, and the activities reflect their in vitro K+-channel opening activity.This led to further evaluation of compound 8a and the selection of the (-)-enantiomer 8b (RP 52891) for development as an antihypertensive and antianginal agent.