13189-98-5 Usage
Description
Fudosteine, also known as Cleanal, is a cysteine derivative that acts as a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor. It is an off-white powder obtained from L-cysteine by condensation with either allylic alcohol in the presence of potassium persulfate or the corresponding bromoalcohol in the presence of a base. Fudosteine possesses antioxidant properties and is effective in reducing mucus glycoprotein hypersecretion, inhibiting infiltration of airway mucosa by lymphocytes and inflammatory cells, and suppressing blood flow of tracheal microvasculature increased by SO2.
Uses
Used in Respiratory Applications:
Fudosteine is used as an anti-inflammatory expectorant for the treatment of MUC5 mucin obstructive pulmonary disease. It interferes with the increase in goblet cell number, expression of the mucin MUC5AC, and subsequent mucin secretion in airways agonized with tobacco smoke, isoproterenol, lipopolysaccharide, TNF-α, or oxidants. Fudosteine limits NF-κB signaling and reduces inflammatory gene expression, making it a promising pharmaceutical candidate for respiratory conditions.
Used in Bronchitis and Respiratory Congestion Treatment:
Fudosteine is used as a mucoactive agent for the treatment of bronchitis and respiratory congestion. It was launched in Japan and has been shown to significantly reduce mucus glycoprotein hypersecretion and inhibit infiltration of airway mucosa by lymphocytes and inflammatory cells in bronchitic rats. When given to bronchitic rabbits, an oral dose of 500 mg/kg daily potently decreased the fucose/N-acetylneuraminic acid in sputa, exhibiting mucoregulatory properties.
Used in Antioxidant Applications:
Fudosteine, a thiol compound with antioxidant properties, is used to limit NF-κB signaling and reduce inflammatory gene expression. It has greater bioavailability than N-acetyl-cysteine and increases cysteine levels in cells, making it a valuable component in antioxidant therapies.
Used in Pharmaceutical Industry:
Fudosteine is used in the pharmaceutical industry as a key ingredient in the development of drugs targeting respiratory conditions and inflammation. Its unique properties as a mucoactive agent and antioxidant make it a valuable asset in the creation of novel treatments for various respiratory diseases and inflammatory disorders.
Originator
SS Pharmaceutical/Mitsubishi Pharma (Japan)
Hazard
A reproductive hazard.
Check Digit Verification of cas no
The CAS Registry Mumber 13189-98-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,1,8 and 9 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 13189-98:
(7*1)+(6*3)+(5*1)+(4*8)+(3*9)+(2*9)+(1*8)=115
115 % 10 = 5
So 13189-98-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H13NO3S/c7-5(6(9)10)4-11-3-1-2-8/h5,8H,1-4,7H2,(H,9,10)
