131948-12-4

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 6-nitro-2-phenyl-
• CAS NO: 131948-12-4
• Molecular Formula: C15H9NO4
• Molecular Weight: 267.241
• Mol File: 131948-12-4.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 6-nitro-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 6-nitro-2-phenyl-(131948-12-4)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 6-nitro-2-phenyl-(131948-12-4)

Safety Data

• Hazardous Substances Data: 131948-12-4(Hazardous Substances Data)

Upstream product

• 1033048-68-8 1-(2-hydroxy-5-nitrophenyl)-3-phenylpropane-1,3-dione 
• 97-51-8 5-Nitrosalicylaldehyde 
• 536-74-3 phenylacetylene 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 70-11-1 α-bromoacetophenone 
• 68043-53-8 6-nitrochroman-4-one 
• 144432-80-4 2-(biphenyl-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 22528-79-6 7-nitrochroman-4-one 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 100-02-7 4-nitro-phenol 
• 1008105-70-1 2-(1-hydroxy-3-phenylprop-2-yn-1-yl)-4-nitrophenol 
• 51484-05-0 6-nitro-chromen-4-one 
• 98-80-6 phenylboronic acid 
• 100-42-5 styrene 

Downstream Products

• 100914-07-6 3-bromo-6-nitro-2-phenyl-chromen-4-one 

Relevant articles and documents

Divergent synthesis of flavones and flavanones from 2′-hydroxydihydrochalconesviapalladium(ii)-catalyzed oxidative cyclization

Divergent and versatile synthetic routes to flavones and flavanonesviaefficient Pd(ii) catalysis are disclosed. These Pd(ii) catalyses expediently provide a variety of flavones and flavanones from 2′-hydroxydihydrochalcones as common intermediates, depending on oxidants and additives,viadiscriminate oxidative cyclization sequences involving dehydrogenation, respectively, in a highly atom-economic manner.

One Pot Synthesis of γ-Benzopyranones via Iron-Catalyzed Aerobic Oxidation and Subsequent 4-Dimethylaminopyridine Catalyzed 6-endo Cyclization

One-pot synthesis of γ-benzopyranones was realized in decent yields and excellent regioselectivities via iron-catalyzed aerobic oxidation and 4-dimethylaminopyridine-catalyzed cyclization of related propargylic alcohols. Derivatizations to aromatic substituted γ-benzopyranones and synthesis of naturally occurring 3′,4′-dimethoxyflavone have also been realized. (Figure presented.).

Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE2 in LPS-induced RAW 264.7 cells

In an effort to identify novel anti-inflammatory compounds, a series of flavone derivatives were synthesized and biologically evaluated for their inhibitory effects on the production of nitric oxide (NO) and prostaglandin E2 (PGE2), representative pro-inflammatory mediators, in LPS-induced RAW 264.7 cells. Their structure-activity relationship was also investigated. In particular, we found that compound 3g displayed more potent inhibitory activities on PGE2 production, similar inhibitory activities on NO production and less weak cytotoxicity than luteolin, a natural flavone known as a potent anti-inflammatory agent.