1319716-42-1

Basic information

• Product Name: 2-Boc-7-oxo-2-Azaspiro[4.4]nonane
• Synonyms: 2-Boc-7-oxo-2-Azaspiro[4.4]nonane;tert-butyl 7-oxo-2-azaspiro[4.4]nonane-2-carboxylate;2-Boc-7-oxo-2-Azaspiro[4.4]nonane - X10653;tert-butyl 7-oxo-2-azaspiro[4.4]nonane-2-carboxylate(WX101862)
• CAS NO: 1319716-42-1
• Molecular Formula: C₁₃H₂₁NO₃
• Molecular Weight: 239.31074
• Mol File: 1319716-42-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 348.6±25.0 °C(Predicted)
• Appearance: /
• Density: 1.12±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -0.76±0.20(Predicted)
• CAS DataBase Reference: 2-Boc-7-oxo-2-Azaspiro[4.4]nonane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Boc-7-oxo-2-Azaspiro[4.4]nonane(1319716-42-1)
• EPA Substance Registry System: 2-Boc-7-oxo-2-Azaspiro[4.4]nonane(1319716-42-1)

Safety Data

• Hazardous Substances Data: 1319716-42-1(Hazardous Substances Data)

Usage

Description

2-Boc-7-oxo-2-Azaspiro[4.4]nonane, also known as tert-Butyl 7-Oxo-2-azaspiro[4.4]nonane-2-carboxylate, is a chemical compound with a unique spirocyclic structure. It is characterized by the presence of a Boc-protected oxo group and a carboxylate moiety. 2-Boc-7-oxo-2-Azaspiro[4.4]nonane is of interest in the field of medicinal chemistry due to its potential applications in the development of novel therapeutic agents.

Uses

Used in Pharmaceutical Industry:
2-Boc-7-oxo-2-Azaspiro[4.4]nonane is used as a reagent for preparing inhibitors of the menin-MLL interaction. The menin-MLL interaction is a crucial regulatory mechanism in gene expression and has been implicated in various diseases, including cancer. By inhibiting this interaction, it is possible to modulate gene expression and develop targeted therapies for the treatment of these diseases.

Upstream product

• 1319716-41-0 tert-butyl 7-hydroxy-2-azaspiro[4.4]nonane-2-carboxylate 
• 1319716-35-2 tert-butyl 3,3-diallyl-2-oxopyrrolidine-1-carboxylate 
• 1319716-36-3 tert-butyl 1-oxo-2-azaspiro[4.4]nonan-7-ene-2-carboxylate 
• 85909-08-6 tert-butyl 2-oxopyrrolidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

Substituted heteroaryl compounds and compositions and uses thereof

The invention provides a substituted heteroaryl compound and a composition thereof, and applications of the compound and the composition. The compound is a compound as shown in a formula I, or stereoisomer, tautomer, oxynitride, solvate, metabolite, pharmaceutically-acceptable salt or prodrug of the compound as shown in the formula I. The invention also provides a pharmaceutical composition containing the above-mentioned compound; and the above-mentioned compound and the pharmaceutical composition are capable of adjusting the activity of JAK kinases and are applied in prevention, treatment, therapy and alleviation of JAK kinase mediated diseases or disorders.

SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE

The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, treating or lessening the severity of a JAK-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of JAK-mediated disease.

A diversity-oriented-synthesis protocol for scaffold discovery based on a general synthetic route to spirocycles

A diversity-oriented synthesis (DOS) protocol for scaffold discovery is described. A general synthetic route is developed from a single lactam for the access to various multi-functionalized spirocyclic keto-lactams and their derived spirocyclic keto-amines. This work provides the foundation for a sequential DOS strategy from scaffold discovery to drug discovery.