132-75-2Relevant articles and documents
Rossi et al.
, p. 1252,1256 (1976)
Mechanistic Insight Facilitates Discovery of a Mild and Efficient Copper-Catalyzed Dehydration of Primary Amides to Nitriles Using Hydrosilanes
Liu, Richard Y.,Bae, Minwoo,Buchwald, Stephen L.
, p. 1627 - 1631 (2018)
Metal-catalyzed silylative dehydration of primary amides is an economical approach to the synthesis of nitriles. We report a copper-hydride(CuH)-catalyzed process that avoids a typically challenging 1,2-siloxane elimination step, thereby dramatically increasing the rate of the overall transformation relative to alternative metal-catalyzed systems. This new reaction proceeds at ambient temperature, tolerates a variety of metal-, acid-, or base-sensitive functional groups, and can be performed using a simple ligand, inexpensive siloxanes, and low catalyst loading.
Straightforward conversion of alcohols into nitriles
Tarrade-Matha, Aurelie,Pillon, Florence,Doris, Eric
, p. 1646 - 1649 (2010)
The reaction of various alcohols with cyanogen bromide, triphenylphosphine, and a base afforded the corresponding nitrile in satisfactory yields. Copyright
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Rossi et al.
, p. 3371 (1976)
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Preparation method of naphthalene ring C marked α .
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, (2021/10/05)
The invention discloses C labeled α - naphthalene acetic acid preparation method and belongs to the field of radioisotope C labeled compounds. C-labeled α - naphthylacetic acid preparation method, C radioisotope labeling is introduced on a naphthalene ring structure α -naphthol acid, C labeling site is in α-position. The method has the advantages that the reaction raw materials are easily available, the synthesis steps are high in yield, the total yield is more 60%, C marker isotopes are less in use amount, and waste is generated. The marker site α-position on the naphthalene ring is less likely to be metabolized compared to C-labeled branched acetic acid, and the synthesized C-labeled compound provides a better study of α -naphthoic acid in the environment.
Method for dehydrating primary amide into nitriles under catalysis of cobalt
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Paragraph 0078-0080, (2021/06/21)
The invention provides a method for dehydrating primary amide into nitrile. The method comprises the following steps: mixing primary amide (II), silane, sodium triethylborohydride, aminopyridine imine tridentate nitrogen ligand cobalt complex (I) and a reaction solvent under the protection of inert gas, carrying out reacting at 60-100 DEG C for 6-24 hours, and post-treating reaction liquid to obtain a nitrile compound (III). According to the invention, an effective method for preparing nitrile compounds by cobalt-catalyzed primary amide dehydration reaction by using the novel aminopyridine imine tridentate nitrogen ligand cobalt complex catalyst is provided; and compared with existing methods, the method has the advantages of simple operation, mild reaction conditions, wide application range of reaction substrates, high selectivity, stable catalyst, high efficiency, and relatively high practical application value in synthesis.
Naphthylacetic acid preparation method
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Paragraph 0037; 0039; 0040; 0047; 0049; 0050; 0057; 0059, (2020/03/12)
The invention discloses a naphthylacetic acid preparation method, which comprises: naphthylacetic acid is prepared by using 1-chloromethylnaphthalene as a starting raw material, using cuprous iodide as a catalyst, using potassium ferrocyanide as a cyanide source and adding triethyl benzyl ammonium chloride as a phase transfer catalyst into a reaction system. According to the invention, traditionalpotassium cyanide or sodium cyanide is replaced with potassium ferrocyanide as the cyanide source, so the safety threat of potassium cyanide or sodium cyanide to operators in a production process isavoided, and environment pollution caused by highly toxic substances is reduced; and the preparation method has advantages of simple post-treatment, low energy consumption and few three-waste.