132139-17-4

Basic information

• Product Name: O,O-bisacetyldaurisoline
• Synonyms: O,O-bisacetyldaurisoline;O,O-diacetyldaurisoline;Di-O-acetyldaurisoline;Daurisoline diacetate
• CAS NO: 132139-17-4
• Molecular Formula: C41H46N2O8
• Molecular Weight: 694.82
• Mol File: 132139-17-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 58-60℃
• Boiling Point: 740.7°Cat760mmHg
• Flash Point: 401.8°C
• Appearance: /
• Density: 1.198±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 8.27E-22mmHg at 25°C
• Refractive Index: 1.586
• CAS DataBase Reference: O,O-bisacetyldaurisoline(CAS DataBase Reference)
• NIST Chemistry Reference: O,O-bisacetyldaurisoline(132139-17-4)
• EPA Substance Registry System: O,O-bisacetyldaurisoline(132139-17-4)

Safety Data

• Hazardous Substances Data: 132139-17-4(Hazardous Substances Data)

Usage

Description

O,O-bisacetyldaurisoline, also known as Daurisoline Diacetate, is a compound derived from the plant source Daurisoline. It is a potent calmodulin antagonist, which means it can inhibit the stimulatory effect of calmodulin on calmodulin-activated cyclic nucleotide phosphodiesterase (CaM-PDE). This property makes it a promising candidate for various applications in different industries.

Uses

Used in Pharmaceutical Industry:
O,O-bisacetyldaurisoline is used as a calmodulin antagonist for its ability to attenuate the stimulatory effect on calmodulin-activated cyclic nucleotide phosphodiesterase (CaM-PDE). This characteristic makes it a potential candidate for the development of drugs targeting various diseases and conditions where calmodulin plays a significant role.
Used in Research Applications:
In the field of research, O,O-bisacetyldaurisoline is used as a tool compound to study the role of calmodulin in cellular processes and signaling pathways. By inhibiting the activity of calmodulin, researchers can gain insights into the mechanisms underlying various biological functions and potential therapeutic targets.
Used in Drug Development:
O,O-bisacetyldaurisoline can be utilized in the development of new drugs targeting calmodulin-related diseases. Its antagonistic properties against calmodulin make it a valuable starting point for designing and synthesizing novel compounds with improved potency, selectivity, and pharmacological properties.

InChI:InChI=1/C41H46N2O8/c1-25(44)49-36-13-10-28(19-35-33-24-41(50-26(2)45)38(47-6)22-30(33)15-17-43(35)4)20-40(36)51-31-11-8-27(9-12-31)18-34-32-23-39(48-7)37(46-5)21-29(32)14-16-42(34)3/h8-13,20-24,34-35H,14-19H2,1-7H3/t34-,35-/m1/s1