1321580-93-1

Basic information

• Product Name: 1-(3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)-5-iodouracil
• Synonyms: 1-(3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)-5-iodouracil
• CAS NO: 1321580-93-1
• Molecular Weight: 598.298
• Mol File: 1321580-93-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)-5-iodouracil(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)-5-iodouracil(1321580-93-1)
• EPA Substance Registry System: 1-(3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-β-D-erythro-pentofuranos-1-yl)-5-iodouracil(1321580-93-1)

Safety Data

• Hazardous Substances Data: 1321580-93-1(Hazardous Substances Data)

Upstream product

• 122111-01-7 2-deoxy-2,2-difluoro-D-erythro-pentonic acid γ-lactone 3,5-dibenzoate 
• 1173824-58-2 (2R,3R)-2-((benzoyloxy)methyl)-4,4-difluoro-5-hydroxyoxolan-3-yl benzoate 
• 38953-72-9 5-iodo-2,4-bis-O-trimethylsilyluracil 
• 134877-42-2 3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose 

Downstream Products

• 1321581-01-4 C₂₉H₂₇F₂IN₃O₉P 
• 1321581-00-3 C₁₉H₂₁F₂IN₃O₉P 
• 1321580-98-6 C₂₅H₂₅F₂IN₃O₉P 

Relevant articles and documents

Design, synthesis and biological evaluation of 2′-deoxy-2′, 2′-difluoro-5-halouridine phosphoramidate ProTides

We report the synthesis of a series of novel 2′-deoxy-2′, 2′-difluoro-5-halouridines and their corresponding phosphoramidate ProTides. All compounds were evaluated for antiviral activity and for cellular toxicity. Interestingly, 2′-deoxy-2′,2′-difluoro-5-iodo- and -5-bromo-uridines showed selective activity against feline herpes virus replication in cell culture due to a specific recognition (activation) by the virus-encoded thymidine kinase.