1321624-40-1

Basic information

• Product Name: (6R)-N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride
• CAS NO: 1321624-40-1
• Molecular Weight: 319.834
• Mol File: 1321624-40-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (6R)-N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (6R)-N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride(1321624-40-1)
• EPA Substance Registry System: (6R)-N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride(1321624-40-1)

Safety Data

• Hazardous Substances Data: 1321624-40-1(Hazardous Substances Data)

Upstream product

• 58019-67-3 (+)-(1Ξ,4R)-4-methyl-2-oxo-cyclopentanecarboxylic acid ethyl ester 
• 80846-04-4 (R)-3-methyl-1,6-hexanedioic acid diethyl ester 
• 623-82-5 (R)-3-methylhexanedioic acid 
• 5961-59-1 N-methyl-N-(4-methoxyphenyl)amine 

Relevant articles and documents

Synthesis and biological activities of (R)- and (S)- N -(4-Methoxyphenyl)- N,2,6-trimethyl-6,7-dihydro-5 H -cyclopenta[ d ]pyrimidin-4-aminium chloride as potent cytotoxic antitubulin agents

(R,S)-1 is a potent antimitotic compound. (R)-1·HCl and (S)-1·HCl were synthesized from (R)- and (S)-3-methyladipic acid. Both enantiomers were potent inhibitors of cell proliferation and caused cellular microtubule loss and mitotic arrest. They inhibited purified tubulin assembly and the binding of [3H]colchicine to tubulin, with (S)-1 being about twice as potent. Cytotoxicity against 60 tumor cell lines, however, indicated that the (S)-isomer was 10- to 88-fold more potent than the (R)-isomer.