132245-78-4

Basic information

• Product Name: L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 5-methyl 1-(phenylmethyl) ester
• CAS NO: 132245-78-4
• Molecular Formula: C18H25NO6
• Molecular Weight: 351.4
• Mol File: 132245-78-4.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 5-methyl 1-(phenylmethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 5-methyl 1-(phenylmethyl) ester(132245-78-4)
• EPA Substance Registry System: L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 5-methyl 1-(phenylmethyl) ester(132245-78-4)

Safety Data

• Hazardous Substances Data: 132245-78-4(Hazardous Substances Data)

Upstream product

• 30924-93-7 Boc-Glu-OBn 
• 79-22-1 methyl chloroformate 
• 67-56-1 methanol 
• 45214-91-3 (2S)-2-[(tert-butoxy)carbonylamino]-4-(methoxycarbonyl)butanoic acid 
• 100-44-7 benzyl chloride 
• 186581-53-3 diazomethane 
• 31139-36-3 dibenzyl dicarbonate 
• 112159-16-7 2-((tert-butoxycarbonyl)amino)-5-methoxy-5-oxopentanoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 74-88-4 methyl iodide 

Downstream Products

• 45214-91-3 (2S)-2-[(tert-butoxy)carbonylamino]-4-(methoxycarbonyl)butanoic acid 
• 92077-74-2 C₁₃H₁₇O₄N*HCl 
• 1383808-20-5 5-methyl N-benzoyl-L-phenylalanyl-L-glutamate 
• 1383808-21-6 C₂₆H₃₂N₂O₆ 
• 1383808-22-7 C₂₆H₃₂N₂O₆ 
• 1383808-24-9 C₂₉H₃₀N₂O₅ 
• 1383808-23-8 C₂₉H₃₀N₂O₅ 
• 1383808-26-1 C₂₇H₃₄N₂O₅ 
• 1383808-25-0 C₂₇H₃₄N₂O₅ 
• 1383808-11-4 1-benzyl 5-methyl N-benzoyl-L-phenylalanyl-L-glutamate 
• 1383808-10-3 1-benzyl 5-methyl N-(tert-butoxycarbonyl)-L-phenylalanyl-L-glutamate 
• 91229-86-6 tert-butyl (S)-2-<(tert-butyloxycarbonyl)amino>-5-bromopentanoate 
• 1621924-38-6 (2S,4S)-2-tert-butoxycarbonylamino-4-methylpentanedioic acid 1-benzyl ester 5-methyl ester 
• 1621924-51-3 (2S,4S)-4-amino-4-[2-(4-fluorophenyl)-1,1-dimethylethylcarbamoyl]-2-methylbutyric acid methyl ester trifluoroacetate 

Relevant articles and documents

Synthesis of the 'northern-hemisphere' fragments of the thiopeptide antibiotic nosiheptide

The northern-hemisphere fragments 4 and 5 of the thiopeptide antibiotic nosiheptide have been synthesized from Boc-Glu-OBn 7 and Boc-Thr 12 in 21.8% and 16.8% overall yields, respectively. Georg Thieme Verlag Stuttgart.

Steric-Free Bioorthogonal Labeling of Acetylation Substrates Based on a Fluorine-Thiol Displacement Reaction

We have developed a novel bioorthogonal reaction that can selectively displace fluorine substitutions alpha to amide bonds. This fluorine-thiol displacement reaction (FTDR) allows for fluorinated cofactors or precursors to be utilized as chemical reporters, hijacking acetyltransferase-mediated acetylation both in vitro and in live cells, which cannot be achieved with azide- or alkyne-based chemical reporters. The fluoroacetamide labels can be further converted to biotin or fluorophore tags using FTDR, enabling the general detection and imaging of acetyl substrates. This strategy may lead to a steric-free labeling platform for substrate proteins, expanding our chemical toolbox for functional annotation of post-translational modifications in a systematic manner.

COMPLEX

PROBLEM TO BE SOLVED: To provide a substance that can be used in a simple quantitative method for desmosines. SOLUTION: In the complex of the present invention, desmosine is bound to a protein directly or via a linking group at the side chain terminal of the 4-position of the pyridine ring of desmosine. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT