132255-78-8

Basic information

• Product Name: Ethanone, 1-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxyphenyl]-
• CAS NO: 132255-78-8
• Molecular Formula: C15H24O3Si
• Molecular Weight: 280.439
• Mol File: 132255-78-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxyphenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxyphenyl]-(132255-78-8)
• EPA Substance Registry System: Ethanone, 1-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxyphenyl]-(132255-78-8)

Safety Data

• Hazardous Substances Data: 132255-78-8(Hazardous Substances Data)

Upstream product

• 288-32-4 1H-imidazole 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 69404-94-0 O-tert-butyldimethylsilylvanillin 
• 74-88-4 methyl iodide 
• 121-33-5 vanillin 

Downstream Products

• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 
• 132255-73-3 <(S)-1-Benzyl-2-<(R)-2-<2-(4-tert.-butyldimethylsilyloxy-3-methoxyphenyl)-2-oxoethyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat 
• 132255-77-7 <(S)-1-Benzyl-2-<(S)-2-<2-(4-tert.-butyldimethylsilyloxy-3-methoxyphenyl)-2-oxoethyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat 
• 132255-80-2 <(S)-1-Benzyl-2-<(S)-2-<2-(4-hydroxy-3-methoxyphenyl)-2-oxoethyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat 
• 132255-79-9 <(S)-1-Benzyl-2-<(R)-2-<2-(4-hydroxy-3-methoxyphenyl)-2-oxoethyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat 
• 132340-25-1 (R)-Norruspolin 
• 67270-82-0 2-Methoxy-4-((E)-(S)-2-pyrrolidin-2-yl-vinyl)-phenol 
• 132255-85-7 <(S)-1-Benzyl-2-<(R)-2-<2-(4-tert.-butyldimethylsilyloxy-3-methoxyphenyl)-2(R)-hydroxyethyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat und <(S)-1-Benzyl-2-<(R)-2-<2-(4-tert.-butyldimethylsilyloxy-3-methoxyphenyl)-2(S)-hydroxyethyl>-pyrrolidino ... 
• 132255-86-8 <(S)-1-Benzyl-2-<(R)-2-<2(4-tert.-butyldimethylsilyloxy3-methoxyphenyl)-ethenyl>-pyrrolidino>-2-oxoethyl>-2,2-dimethylpropionat 
• 132255-68-6 1-(tert.-Butyldimethylsilyloxy)-2-methoxy-4-(1-trimethylsilyloxyethenyl)-benzol 

Relevant articles and documents

Taming of a superbase for selective phenol desilylation and natural product isolation

Hydroxyl moieties are highly prevalent in natural products. We previously reported a chemoselective strategy for enrichment of hydroxyl-functionalized molecules by formation of a silyl ether bond to a resin. To generate smaller pools of molecules for analysis, we developed cleavage conditions to promote stepwise release of phenolic silyl ethers followed by aliphatic silyl ethers with a "tamed" version of the superbase 1,1,3,3-tetramethylguanadine. We demonstrate this as a general strategy for selective deprotection of phenolic silyl ethers under neutral conditions at room temperature.

A Facile Synthesis of Aldehyde and Ketone via Sonochemical Barbier Reaction and Oxidation

Methyl ketone is prepared by a sonochemical Barbier reaction of methyl iodide, magnesium powder and aldehyde in Benzene/THF (9/1) solvent in a commercial ultrasonic cleaning bath (39 kHz), followed by the addition of N-chlorosuccinimide (NCS) as an oxidizing agent.